Author

Renee Chang

Koch Institute for Integrative Cancer Research At MIT

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1

Frequent Co-Authors

Matthew G. Vander HeideniD· 2 shared Sarah M ChangiD· 2 shared Anna Shevzov-Zebrun· 1 shared Brian T. DoiD· 1 shared Craig J. ThomasiD· 1 shared David O. HollandiD· 1 shared Gillian E. OaksiD· 1 shared Huel Cox· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Matthew G. Vander HeidenORCID

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2 papers

Recent·Most cited

Cysteine-mediated bortezomib resistance is governed by α-ketoacid availability

Jennifer A. Brain, Sarah M Chang, Maximilian Kobiesa, Leah G. Rector, Michele Ceribelli, Sky H. Kim, Zhaoqi Li, Brian T. Do, Kelli J. Che, David O. Holland, Samuel Block, Renee Chang, Gillian E. Oaks, Craig J. Thomas, Matthew G. Vander Heiden, Lucas B. Sullivan

This study shows that α-ketoacids enhance the effectiveness of bortezomib by reducing cysteine-mediated detoxification, thereby increasing proteasome inhibition and cytotoxicity.

bioRxiv · Jul 7, 2026 · PreprintCancer Biology

Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

Sarah M Chang, Muhammad Bin Munim, S Trojan, Huel Cox, Anna Shevzov-Zebrun, Keene L. Abbott, Renee Chang, Matthew G. Vander Heiden

The paper shows cancer cells adjust mitochondrial respiration to alter NAD+/NADH ratios, enhancing biomass synthesis and proliferation under nutrient limitation.

bioRxiv · May 9, 2025 · PreprintCancer Biology