Ultrasensitive single-genome sequencing reveals strong purifying selection in acute HIV-1 infection
Adam A. Capoferri, Valerie F. Boltz, Wei Shao, Clarissa Halpern, Rasmi Thomas, Nittaya Phanuphak, Lydie Trautmann, Sandhya Vasan, Carlo Sacdalan, Somchai Sriplienchan, John W. Mellors, John M. Coffin, Jason W. Rausch, Mary F. Kearney
This study uses ultra-deep single-genome sequencing to show strong purifying selection in early HIV-1 infection, with limited early genetic divergence from founder viruses.
bioRxiv · Aug 26, 2026 · PreprintMicrobiology