Jason W. Rausch

Ultrasensitive single-genome sequencing reveals strong purifying selection in acute HIV-1 infection

This study uses ultra-deep single-genome sequencing to show strong purifying selection in early HIV-1 infection, with limited early genetic divergence from founder viruses.

In vivo detection of HIV-1 antisense transcripts in untreated and ART-treated individuals

This study detects HIV-1 antisense transcripts in vivo, showing higher expression in ART-treated individuals compared to untreated ones, suggesting a regulatory role in viral expression.

HIV-1 Viremia Not Suppressible By Antiretroviral Therapy Can Originate from Large T-Cell Clones Producing Infectious Virus

The paper identifies large T-cell clones producing infectious HIV-1 virus as a source of non-suppressible viremia despite ART adherence and no drug resistance.

Interplay of primary sequence and RNA secondary structure in determining 5′ splice site choice

The paper investigates how primary RNA sequence and secondary structure influence 5' splice site selection in vivo using a model of Hutchinson-Gilford Progeria Syndrome.