Distinct Perception Mechanisms of BACH1 Quaternary Structure Degrons by Two F-box Proteins under Oxidative Stress
Shiyun Cao, Sheena Faye Garcia, Huigang Shi, Ellie I. James, Yuki Kito, Hui Shi, Haibin Mao, Sharon Kaisari, Gergely Róna, Sophia Deng, Hailey V. Goldberg, Jackeline Ponce, Beatrix M. Ueberheide, Luca Lignitto, Miklós Guttman, , Ning Zheng
This study reveals how two F-box proteins, FBXO22 and FBXL17, recognize distinct structural features of the BACH1 BTB dimer under oxidative stress, leading to its ubiquitination and degradation.
Cell · Nov 5, 2024Peer-reviewedCancer Biology