Author

Sowmya Srinivasan

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Assay:CUT&Tag· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Lindsay MoritziD· 2 shared Mashiat RabbaniiD· 2 shared Ritvija AgrawaliD· 2 shared Saher Sue HammoudiD· 2 shared Alan P. BoyleiD· 1 shared Alexander VargoiD· 1 shared Bluma J. LeschiD· 1 shared Bradley Robert CairnsiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenomics

Lindsay MoritzORCID

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Author profile →

2 papers

Recent·Most cited

3D chromatin compartment of round spermatids encodes the spatiotemporal program of histone-to-protamine exchange in spermiogenesis

Mashiat Rabbani, Zachary Apell, Timothy J. Parnell, Lindsay Moritz, Sion Kim, Sowmya Srinivasan, Ritvija Agrawal, Alexander Vargo, Peter Orchard, Wenxin Xie, Lydia Freddolino, Alan P. Boyle, Jun Z. Li, Bluma J. Lesch, Bradley Robert Cairns, , Saher Sue Hammoud

The paper defines a 3D chromatin compartment blueprint that programs histone-to-protamine exchange during spermiogenesis using ATAC-seq, CUT&Tag, and Hi-C.

bioRxiv · Mar 12, 2026 · PreprintGenomics

A hidden protamine PTM code in sperm generates heterogeneous chromatin states and finetunes reproductive fitness

Lindsay Moritz, Christopher J. Woodilla, Ritvija Agrawal, Mashiat Rabbani, Samantha B. Schon, Wen Qin Xie, Catherine A. Tower, Sowmya Srinivasan, Yi Sheng, Michael R. Baldwin, Patrick O’Brien, Rex A. Hess, Kyle E. Orwig, Sy Redding, Saher Sue Hammoud

This study shows that protamine PTMs create heterogeneous chromatin states in sperm, affecting fertility and chromatin integrity.

bioRxiv · Nov 18, 2025 · PreprintMolecular Biology