Synaptotagmin 1 mediates toxicity of botulinum neurotoxin type A
Merja Joensuu, Parnayan Syed, Saber H. Saber, Vanessa Lanoue, Tristan P. Wallis, James A. Rae, Ailisa Blum, Rachel S. Gormal, Christopher Small, Shanley F. Longfield, Anmin Jiang, Stefan Mahrhold, Nadja Krez, Michael Alan Cousin, Ruby Cooper‐White, , Frédéric A. Meunier
This paper shows that botulinum neurotoxin type A (BoNT/A) toxicity relies on synaptotagmin 1 (Syt1), which forms nanoclusters with PSG and SV2 on neuronal membranes, enabling endocytic targeting and neuronal communication disruption.
The EMBO Journal · May 25, 2023Peer-reviewedNeuroscience