Oncofetal RNA-binding proteins of IGF2BP family suppress IRF-3 and NF-kB dependent transcription downstream of cytosolic RNA sensors
Garrett Knox, Ruba Agili-Shaban, Alexis Morrissey, Karamveer Karamveer, Ahsan Polash, Maria Wohlbowne, Stefanija Kinzy, Cheryl A. Keller, Todd D. Schell, Jeremy A. Hengst, George‐Lucian Moldovan, Junjia Zhu, Arati Sharma, Hong Zheng, Edward Harhaj, , Irina A. Elcheva
This study shows that IGF2BP family proteins suppress RNA-sensing pathways by binding TNFAIP3 mRNA, reducing innate immune signaling in AML cells.
bioRxiv · Jul 29, 2026 · PreprintCancer Biology