Epigenetic regulation of DPP4 receptor expression by NONO enables replication of MERS-CoV
Adam Hage, Mikhaila Janes, Seth D. Scott, Suhyeon Yoon, Kevin Rose, Tovah E. Markowitz, Lara M. Myers, Aaron Carmody, Lenny Triem, Olivia Straw, Kristin L. McNally, Paul A. Beare, Justin Lack, Craig Martens, Sonja M. Best
This study identifies NONO as a host factor that epigenetically regulates DPP4 expression, facilitating MERS-CoV replication by modulating histone modifications at the DPP4 locus.
bioRxiv · Sep 23, 2026 · PreprintMicrobiology