Optogenetic control reveals differential promoter interpretation of transcription factor nuclear translocation dynamics
Susan Y. Chen, Lindsey C. Osimiri, Michael W. Chevalier, Lukasz J. Bugaj, Taylor H. Nguyen, R.A. Greenstein, Andrew H. Ng, Jacob Stewart-Ornstein, Lauren T. Neves, Hana El‐Samad
The paper introduces CLASP, an optogenetic tool to control TF localization, and shows differential promoter responses to pulsatile vs. continuous TF inputs.
Cell Systems · Sep 7, 2020Peer-reviewedSystems Biology