Jason P. Town

The paper extends mathematical models of cell migration by incorporating local negative feedback of Rac activity, showing improved response to dynamic guidance cues and noisy gradients.

PerturbView enables highly multiplexed optical pooled screens in primary cells and tissues by improving barcode amplification, revealing regulators of NFκB signaling and enabling spatial transcriptomics integration.

The paper introduces MTK, a toolkit for rapid modular DNA circuit assembly in mammalian cells, demonstrating its use in constructing an Ebola virus replication complex circuit.

The paper uses deep mutational scanning to explore how chemical perturbations affect ubiquitin's mutational tolerance, revealing sensitization of most positions except two.