T. C. Mettenleiter

Oral immunization of goats and foxes with a recombinant NDV vectored rabies vaccine

This study tests an oral rabies vaccine in goats and foxes, showing it is safe and induces immune responses.

NECing goes: flexibility of the herpesvirus nuclear egress complex

This study examines the structure and flexibility of the herpesvirus nuclear egress complex (NEC) using electron cryo-tomography, revealing its hexameric lattice and role in capsid envelopment.

Spatiotemporal analysis of SARS-CoV-2 infection reveals an expansive wave of monocyte-derived macrophages associated with vascular damage and virus clearance in hamster lungs

This study uses 3D spatiotemporal analysis to show that SARS-CoV-2 infection in hamsters leads to monocyte-derived macrophage infiltration, vascular damage, and virus clearance, followed by tissue remodeling and fibrosis.

CP204L Is a Multifunctional Protein of African Swine Fever Virus That Interacts with The VPS39 Subunit of HOPS Complex and Promotes Lysosome Clustering

This study identifies CP204L as an ASFV protein that interacts with VPS39, altering lysosome dynamics and promoting virus replication.

Low-dose bivalent mRNA vaccine is highly effective against different SARS-CoV-2 variants in a transgenic mouse model

This study shows a low-dose bivalent mRNA vaccine targeting multiple SARS-CoV-2 variants provides strong protection in mice and rats, with comparable antibody levels and reduced viral replication.

Compellingly high SARS-CoV-2 susceptibility of Golden Syrian hamsters suggests multiple zoonotic infections of pet hamsters during the COVID-19 pandemic

This study determines the minimum infective dose of SARS-CoV-2 for Golden Syrian hamsters and highlights their high susceptibility, suggesting a potential zoonotic risk.

Serological screening in wild ruminants in Germany, 2021/22: No evidence of SARS-CoV-2, bluetongue virus or pestivirus spread but high seroprevalences against Schmallenberg virus

The paper serologically screens wild ruminants in Germany for SARS-CoV-2, bluetongue virus, pestivirus, and Schmallenberg virus, finding no evidence of spread but high seroprevalence against Schmallenberg virus and potential cross-reactivity with SARS-CoV-2.

CVnCoV protects human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2

This study evaluates the efficacy of the CVnCoV mRNA vaccine against ancestral and emerging SARS-CoV-2 variants in a human ACE2 transgenic mouse model, showing complete protection against B.1.351.

Preferential selection and contribution of non-structural protein 1 (NS1) to the efficient transmission of the panzootic avian influenza H5N8 2.3.4.4 clades A and B viruses in chickens and ducks

This study identifies NS1 protein length variations in H5N8 avian influenza viruses that affect their transmission and virulence in chickens and ducks.

3D reconstruction of SARS-CoV-2 infection in ferrets emphasizes focal infection pattern in the upper respiratory tract

This study uses 3D imaging to show SARS-CoV-2 preferentially infects the upper respiratory tract of ferrets with a focal pattern in nasal turbinates.

Experimental infection of cattle with SARS-CoV-2

This study infects cattle with SARS-CoV-2 and observes limited replication and sero-reactivity in some animals while in-contact animals remain uninfected.

Susceptibility of raccoon dogs for experimental SARS-CoV-2 infection

This study shows raccoon dogs are susceptible to SARS-CoV-2 infection and can transmit it to direct contact animals, suggesting they may act as intermediate hosts.

Pitfalls in SARS-CoV-2 PCR diagnostics

This study identifies contamination of commercial PCR reagents as a source of false positives in SARS-CoV-2 testing, emphasizing the need for rigorous validation of reagents before use.