T. G. Graeber

The metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling

This study shows Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling by providing a weak TLR4 signal.

Telomerase reverse transcriptase induces targetable alterations in glutathione and nucleotide biosynthesis in glioblastomas

This study identifies metabolic vulnerabilities in glioblastomas driven by TERT and shows that combining GCLC and glutamine-utilizing enzyme inhibitors synergistically targets these vulnerabilities.

MITF regulates IDH1 and NNT and drives a transcriptional program protecting cutaneous melanoma from reactive oxygen species

The paper shows MITF promotes melanoma survival by increasing resistance to reactive oxygen species through regulating antioxidant genes like IDH1 and NNT.

Plasticity of extrachromosomal and intrachromosomal BRAF amplifications in mediating targeted therapy dosage challenges

This study investigates how BRAF amplifications in different genomic forms enable melanoma cells to adapt to targeted therapy dose changes, revealing mechanisms of drug resistance.

Quantitative single cell heterogeneity profiling of patient derived tumor initiating gliomaspheres reveals unique signatures of malignancy and response

The paper uses single cell proteomic analysis to identify distinct signaling phenotypes in gliomaspheres, revealing EGFR and AKT/TORC1 signaling divergence and potential therapeutic targets.