Author

T. H. Flo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2

Frequent Co-Authors

A. Marstad· 3 shared M. Haug· 3 shared M. Steigedal· 2 shared T. R. Ioerger· 2 shared A. Gidon· 1 shared A. Volchuk· 1 shared B. E. Steinberg· 1 shared B. Kilburn· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersImmunology

A. Marstad

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Pyruvate supports RET-dependent mitochondrial ROS production necessary to control Mycobacterium avium infection in human primary macrophages

L. M. Rost, C. Louet, P. Bruheim, T. H. FLO, A. Gidon

This study shows that pyruvate import into mitochondria drives ROS production, which helps control Mycobacterium avium infection in human macrophages.

bioRxiv · Feb 1, 2022Immunology

Glycine targets NINJ1-mediated plasma membrane rupture to provide cytoprotection

J. P. Borges, R. S. R. Satra, A. Volchuk, M. Bugge, B. Kilburn, N. M. Goldenberg, T. H. FLO, B. E. Steinberg

This paper identifies NINJ1 as the molecular target of glycine's cytoprotective effect against plasma membrane rupture in lytic cell death.

bioRxiv · Dec 12, 2021 · PreprintCell Biology

The proteomic landscape of resting and activated CD4+ T cells reveal insights into cell differentiation and function

Y. Subbannayya, M. Haug, S. Pinto, V. Mohanty, H. Z. Meas, T. H. Flo, T. S. K. Prasad, R. K. Kandasamy

This study uses proteomic profiling to compare resting and activated human CD4+ T cells, identifying protein changes linked to activation, differentiation, and immune function.

bioRxiv · Nov 17, 2020Immunology

Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection

K. S. Beckwith, M. S. Beckwith, S. Ullmann, R. S. R. Saetra, H. Kim, A. Marstad, S. E. Asberg, T. A. Strand, H. Stenmark, T. H. Flo

This study identifies a novel mechanism where plasma membrane damage during Mycobacterium tuberculosis infection triggers NLRP3-mediated pyroptosis and facilitates bacterial spread.

bioRxiv · Aug 28, 2019Immunology

Global assessment of Mycobacterium avium subspecies hominissuis genetic requirement for growth and virulence.

M. S. Dragset, T. R. Ioerger, M. Loevenich, M. Haug, N. Sivakumar, A. Marstad, P. J. Cardona, G. Klinkenberg, E. J. Rubin, M. Steigedal, T. H. Flo

This study identifies genetic requirements for growth and virulence in Mycobacterium avium subsp. hominissuis using transposon mutagenesis, revealing shared and unique genes with M. tuberculosis.

bioRxiv · Mar 5, 2019 · PreprintMicrobiology

Genetic variation/evolution and differential host responses resulting from in-patient adaptation of Mycobacterium avium

N. Kannan, Y.-P. Lai, M. Haug, K. Lilleness, S. S. Bakke, A. Marstad, H. Hov, T. Naustdal, J. E. Afset, T. R. Ioerger, T. H. Flo, M. Steigedal

This study examines genetic changes in Mycobacterium avium isolates from infected patients over time and links these changes to altered host immune responses and increased bacterial persistence.

bioRxiv · Apr 10, 2018Immunology