Author

S. Pinto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

R. K. Kandasamy· 3 shared Y. Subbannayya· 3 shared T. S. K. Prasad· 2 shared A. C. Cheng· 1 shared A. Chan· 1 shared A. Navon· 1 shared A. Pironet· 1 shared A. Saigal· 1 shared

Activity by Year

2019-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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3 shared papersImmunology

R. K. Kandasamy

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7 papers

Recent·Most cited

Large-scale deployment and establishment of Wolbachia into the Aedes aegypti population in Rio de Janeiro, Brazil.

J. S. M. Gesto, S. Pinto, F. B. S. Dias, J. Peixoto, G. Costa, S. Kutcher, J. Montgomery, B. R. Green, K. L. Anders, P. A. Ryan, C. P. Simmons, S. L. O'Neill, L. A. Moreira

This study reports the large-scale release of Wolbachia-infected Aedes aegypti mosquitoes in Brazil, showing successful invasion with infection rates of 30-70% in two areas.

bioRxiv · Apr 29, 2021Microbiology

The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy

Y. Guo, J. Yu, Y. Wu, H. Gong, S. Kesteven, S. E. Iismaa, A. Chan, S. Holman, S. Pinto, A. Pironet, C. Cox, R. Vennekens, R. M. Graham, M. P. Feneley, B. Martinac

This study identifies TRPM4 as a key regulator of pressure overload-induced cardiac hypertrophy by modulating CaMKII{delta}-HDAC4-MEF2A and calcineurin-NFAT-GATA4 pathways in mice.

bioRxiv · Dec 21, 2020Physiology

The proteomic landscape of resting and activated CD4+ T cells reveal insights into cell differentiation and function

Y. Subbannayya, M. Haug, S. Pinto, V. Mohanty, H. Z. Meas, T. H. Flo, T. S. K. Prasad, R. K. Kandasamy

This study uses proteomic profiling to compare resting and activated human CD4+ T cells, identifying protein changes linked to activation, differentiation, and immune function.

bioRxiv · Nov 17, 2020Immunology

Discovery of A New Class of Integrin Antibodies for Fibrosis

J. Zhang, T. Wang, A. Saigal, J. Johnson, J. Morrisson, S. Tabrizifard, S. A. Hollingsworth, M. J. Eddins, W. Mao, K. O'Neill, M. Garcia-Calvo, E. Carballo-Jane, D. Liu, T. Ham, Q. Zhou, , M. Handa

The paper identifies new integrin antibodies that inhibit fibrosis progression in lung injury models and show superior in vitro activity in fibroblasts.

bioRxiv · Jul 20, 2020Pharmacology & Toxicology

Dose-dependent phorbol 12-myristate-13-acetate-1 mediated monocyte-to-macrophage differentiation induces unique proteomic signatures in THP-1 cells

S. Pinto, H. Kim, Y. Subbannayya, M. Giambelluca, K. Boesl, R. K. Kandasamy

This study investigates how varying PMA concentrations and durations during THP-1 differentiation affect proteomic signatures and cytokine gene expression in macrophage-like cells.

bioRxiv · Feb 27, 2020Immunology

{-}{-}{-}{-}{-}Polyglutamine-related aggregates serve as a potent antigen source for cross presentation by dendritic cells

A. Navon, S. Tabachnick-Cherny, D. Berko, S. Pinto, C. Curato, Y. Wolf, Z. Porat, R. Karmona, B. Tirosh, S. Jung

The paper shows that polyglutamine-related aggregates from apoptotic cells are efficiently processed by dendritic cells for cross-presentation, ensuring antigenic overlap necessary for T cell immunity.

bioRxiv · Oct 15, 2019Cell Biology

Dynamics of dual specificity phosphatases and their interplay with protein kinases in immune signaling

Y. Subbannayya, S. Pinto, K. Bosl, T. S. K. Prasad, R. K. Kandasamy

This study identifies DUSP-mediated hub proteins and pathways in immune signaling using omics datasets, highlighting potential therapeutic targets for disorders with aberrant DUSP signaling.

International Journal of Molecular Sciences · Apr 27, 2019Peer-reviewedImmunology