T. Ha

This study identifies a mechanical code linking DNA sequence to mechanical properties, showing how CpG methylation and sequence features influence DNA shape and gene regulation.

This paper develops loop-seq to measure DNA bendability genome-wide and finds sequence-encoded low bendability upstream of TSSs that influences nucleosome positioning and chromatin remodeling.

The paper uses single-cell microscopy and stochastic modeling to show Hfq stabilizes SgrS and aids its interaction with target mRNA during glucose-phosphate stress in E. coli.

The paper identifies 54% of human PH domain-containing proteins as having PIP binding affinity, using single-molecule pulldown assays and a recursive-learning algorithm.

The paper develops a novel vectorial folding assay to study cotranscriptional riboswitch folding and shows that riboswitch fate is sequence-encoded and controllable by a directionally moving protein.

The paper uses fluorescence-force spectroscopy to study how extra telomeric repeats affect G-quadruplex folding dynamics in human telomeric sequences.

This study examines the nanomechanics and co-transcriptional folding of Spinach and Mango aptamers using single-molecule techniques, revealing distinct unfolding and refolding behaviors and the role of ions in their stability.

The paper evaluates how non-canonical guide RNAs and Cas9 variants affect DNA unwinding, finding that some combinations reduce off-target activity while maintaining on-target efficiency.

This study investigates DNA unwinding by the hexameric helicase G40P using single-molecule fluorescence, revealing single base pair unwinding and coordinated ATP hydrolysis.

The paper examines DNA binding kinetics of TALE arrays using single molecule microscopy and deterministic modeling, revealing functional instability due to conformational heterogeneity.

This study characterizes the DNA interrogation and product release kinetics of three Cpf1 orthologues using single-molecule fluorescence and biochemical assays, revealing differences from Cas9 in binding and cleavage requirements.

This study investigates how the bacterial sRNA SgrS prioritizes and regulates its target mRNAs, revealing that regulatory hierarchy depends on binding site number, position, and cofactors like Hfq.

This study reveals how engineered Cas9 variants improve specificity by altering DNA unwinding dynamics and cleavage rates in response to mismatches.

The paper identifies early antiviral gene expression patterns and shows that RLRs drive stochastic IFNB1 expression independent of IFN.