Author

T. Hatano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 3 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Organism:yeast· 3 Organism:Arabidopsis· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2

Frequent Co-Authors

A. Suchenko· 4 shared M. Balasubramanian· 4 shared H. Hussain· 3 shared L. Sivashanmugam· 3 shared M. K. Balasubramanian· 3 shared B. Baum· 2 shared K. Chinthalapudi· 2 shared M. Mishima· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersBiochemistry

A. Suchenko

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Author profile →

8 papers

Recent·Most cited

Evolutionarily conserved principles of ESCRT-III-mediated membrane remodelling revealed by a two-subunit Asgard archaeal system

D. P. Souza, J. Espadas, S. Chaaban, E. R. R. Moody, T. Hatano, M. Balasubramanian, T. A. Williams, A. Roux, B. Baum

The paper identifies evolutionarily conserved principles of ESCRT-III-mediated membrane remodeling using an Asgard archaeal two-subunit system, showing homology to eukaryotic ESCRT-IIIB and IIIA.

bioRxiv · Jul 1, 2024Evolutionary Biology

Structure and physiological investigation of arginylated actin

C. S. Pinto, S. E. Bakker, A. Suchenko, H. Hussain, T. Hatano, K. Sampath, K. Chinthalapudi, M. Mishima, M. Balasubramanian

This study investigates the structure and function of arginylated beta-actin, showing structural similarity to non-arginylated actin but altered interactions with myosin-II and effects on cellular processes.

bioRxiv · Jun 12, 2024 · PreprintBiochemistry

Connection between drug-mediated neurotransmission and salivary microbiome

D. Hisamatsu, Y. Ogata, H. Takeshige-Amano, W. Suda, T. Hatano, D. Asaoka, Y. Mabuchi, Y. Naraoka, N. Sato, T. Asada, N. Hattori, M. Hattori, C. Akazawa

This study investigates how CNS drugs affect the salivary microbiome and links these changes to cognitive function and neurodegeneration.

bioRxiv · Aug 20, 2023 · PreprintMicrobiology

Structural Mechanisms of Actin Isoforms

A. S. Arora, H.-L. Huang, R. Singh, Y. Narui, T. Hatano, S. Heissler, M. K. Balasubramanian, K. Chinthalapudi, A. Suchenko

The paper reports high-resolution structures of actin isoforms with native PTMs, revealing isoform-specific conformations and their functional implications.

bioRxiv · Aug 1, 2022Biochemistry

mNeonGreen-tagged fusion proteins and nanobodies reveal localization of tropomyosin to patches, cables, and contractile actomyosin rings in live yeast cells

T. Hatano, T. C. Lim, I. Billault-Chaumartin, A. Dhar, Y. Gu, T. Massam-Wu, S. Adhishesha, L. Springall, W. Scott, L. Sivashanmugam, M. Mishima, S. G. Martin, S. Oliferenko, S. Palani, M. K. BALASUBRAMANIAN

The paper develops mNeonGreen-tagged tropomyosin and nanobodies to visualize tropomyosin localization in yeast, revealing new structures and dynamics in actin cytoskeleton.

bioRxiv · May 19, 2022Cell Biology

Characterisation of the Ubiquitin-ESCRT pathway in Asgard archaea sheds new light on origins of membrane trafficking in eukaryotes

T. Hatano, S. Palani, D. Papatziamou, R. Salzer, D. Souza, D. Tamarit, M. Makwana, A. Potter, A. Haig, W. Xu, D. Bellini, D. Townsend, D. Rochester, H. Hussain, T. Ettema, , M. Balasubramanian

This study characterizes the ubiquitin-ESCRT pathway in Asgard archaea, showing its pre-eukaryotic origin and evolutionary path through gene duplication.

bioRxiv · Aug 17, 2021Cell Biology

N-terminal modification of actin by acetylation and arginylation determines the architecture and assembly rate of linear and branched actin networks

S. M. Chin, T. Hatano, L. Sivashanmugam, A. Suchenko, A. S. Kashina, M. K. BALASUBRAMANIAN, S. Jansen

This study shows that acetylation and arginylation of actin's N-terminus differentially regulate actin polymerization dynamics and remodeling by actin-binding proteins, affecting network architecture and assembly rates.

bioRxiv · Jun 25, 2020 · PreprintBiochemistry

Pick-ya actin: A method to purify actin isoforms with bespoke key post-translational modifications

T. Hatano, L. Sivashanmugam, A. Suchenko, H. Hussain, M. Balasubramanian

Pick-ya actin is a method to produce actin isoforms with organism-specific post-translational modifications using synthetic biology in yeast.

bioRxiv · Nov 6, 2019Cell Biology