M. Hattori

Autonomous multicolor bioluminescence imaging in bacteria, mammalian, and plant hosts

The paper develops a multicolor auto-bioluminescence system for use in bacteria, mammalian, and plant hosts, enabling long-term imaging without external substrates.

Creating coveted bioluminescence colors for simultaneous myriad-color bioimaging

The paper introduces a method to expand color variation in bioluminescence by tuning dual-acceptor BRET, enabling up to 20 colors for simultaneous bioimaging.

Structural insights into the orthosteric inhibition of P2X receptors by non-ATP-analog antagonists

The paper determines cryo-EM structures of P2X7 receptor with antagonists and identifies key residues for subtype specificity, aiding in antagonist design.

Connection between drug-mediated neurotransmission and salivary microbiome

This study investigates how CNS drugs affect the salivary microbiome and links these changes to cognitive function and neurodegeneration.

Dimension reduction of microbiome data linked Bifidobacterium to allergic rhinitis

The paper applies dimension reduction methods to microbiome data and links Bifidobacterium to allergic rhinitis risk and nutrient intake.

Structural insights into the allosteric inhibition of P2X4 receptors

This study reports cryo-EM structures of zebrafish P2X4 receptors bound to antagonists, revealing ligand-dependent structural changes that explain subtype-specific allosteric inhibition.

Antithetic effects of agonists and antagonists on the structural fluctuations of TRPV1 channel

This study uses HS-AFM to visualize TRPV1 structural fluctuations, showing agonist RTX increases fluctuations while antagonist CPZ decreases them, affecting channel gating.

High-resolution temporal profiling of the gut microbiome through the whole life of mice

This study tracks the gut microbiome of mice over their entire lifespan, revealing patterns of microbial persistence and age-related changes linked to longevity.

Complex host/symbiont integration of a multi-partner symbiotic system in the eusocial aphid Ceratovacuna japonica

The paper identifies a co-obligate symbiosis in the aphid Ceratovacuna japonica, revealing metabolic complementarity between two endosymbionts and caste-specific differences in symbiont populations.

Extensive gut virome variation and its associations with host and environmental factors in a population-level cohort

The paper analyzes the gut virome in a large cohort, identifying factors influencing virome diversity and its relationship with host and environmental variables.

Genetically-linked simultaneous overexpression of multiple herbicide-metabolizing genes for broad-spectrum resistance in an agricultural weed Echinochloa phyllopogon

The paper identifies genetically linked overexpression of multiple herbicide-metabolizing genes in E. phyllopogon, enhancing and broadening metabolic resistance to multiple herbicides.

Structural insights into the ion selectivity of the MgtE channel for Mg2+ over Ca2+

The paper determines the high-resolution structure of MgtE TM domain with Ca2+ and shows Mg2+ binds 500-fold stronger than Ca2+.

Multiple nutritional and gut microbial factors associated with allergic rhinitis: the Hitachi Health Study

The study identifies four nutrients and two gut microbiome genera associated with reduced risk of allergic rhinitis, with an interaction between retinol and Prevotella.

Identification and mechanistic analysis of an inhibitor of the CorC Mg2+ transporter

The paper identifies a chemical inhibitor of the CorC Mg2+ transporter and provides structural insights into its mechanism of action.

Fluorescence-detection size-exclusion chromatography utilizing nanobody technology for expression screening of membrane proteins

This paper introduces FSEC-Nb, a method using nanobody technology to screen membrane protein expression without GFP fusion, successfully identifying ZAC orthologs and SARS-CoV-2 membrane proteins with high monodispersity.

Cryo-EM structure of the MgtE Mg2+ channel pore domain in Mg2+-free conditions reveals cytoplasmic pore opening

The paper determines the cryo-EM structure of MgtE in Mg2+-free conditions, revealing cytoplasmic pore opening and kink motions in TM2 and TM5 helices.

Deglycosylation of isoflavone C-glucoside puerarin by combination of two recombinant bacterial enzymes and 3-oxo-glucose.

This study identifies and characterizes two bacterial enzymes, DgpA and DgpB-C complex, that work together with 3-oxo-glucose to degrade the C-glucoside puerarin through a β-elimination mechanism.

Revealing microbial assemblage structure in the human gut microbiome using latent Dirichlet allocation

This study uses latent Dirichlet allocation to detect microbial assemblages in the human gut microbiome, revealing four assemblages with distinct compositions and relationships to enterotypes.

Mucin O-glycans facilitate symbiosynthesis to maintain gut immune homeostasis

This study identifies mucin O-glycans as a fermentation substrate for n-butyrate production, which supports immune homeostasis in the gut.