T. J. Kobayashi

Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity

This study identifies C15ORF48 as a mitochondrial protein that induces stress-independent autophagy, reducing oxidative stress and autoimmunity in thymic epithelial cells.

TCR Repertoire Analysis of CD4-Positive T Cells from Blood and an Affected Organ in an Autoimmune Mouse Model

This study examines TCR repertoires in CD4+ T cells from blood and stomachs of AIRE KO mice to correlate TCR diversity with autoimmune symptom variation and organ-specific disease manifestations.

Acceleration of Evolutionary Processes by Learning and Extended Fisher's Fundamental Theorem

This paper shows that ancestral learning can accelerate evolutionary processes by using information from ancestors, and extends Fisher's Fundamental Theorem to quantify this acceleration.

Lineage EM Algorithm for Inferring Latent States from Cellular Lineage Trees

This paper introduces the Lineage EM algorithm to infer latent cell phenotypes from lineage trees while addressing survivorship bias.

Quantitative analysis reveals reciprocal regulations underlying recovery dynamics of thymocytes and thymic environment

The paper quantitatively analyzes thymic crosstalk dynamics during recovery from irradiation, identifying regulatory interactions and predicting a new regulation of CD4+CD8+ thymocytes.

Quantification of inter-sample differences in T cell receptor sequences

This paper introduces a new method to quantify inter-sample differences in T cell receptor sequences by analyzing sequence dissimilarities and identifying key sequences contributing to variation.