M. Miyauchi

Advancing microbial isolation: The impact of leaf mold extract agar on soil samples

This study develops a leaf mold extract agar medium that enhances the isolation of soil microbes not typically cultured in standard media, including an unidentified species.

Establishing a method for the cryopreservation of viable peripheral blood mononuclear cells in the International Space Station

This study develops a cryopreservation method for blood cells under ISS constraints, demonstrating viability recovery and subset analysis using flow cytometry.

Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity

This study identifies C15ORF48 as a mitochondrial protein that induces stress-independent autophagy, reducing oxidative stress and autoimmunity in thymic epithelial cells.

Pseudoirreversible inhibition elicits persistent efficacy of a sphigosine-1-phosphate receptor-1 antagonist

This study identifies KSI-6666 as a pseudoirreversible S1PR1 antagonist that suppresses inflammation through interaction with a methionine residue.

Acute irradiation alters the heterogeneity among medullary thymic epithelial cells 2

This study shows acute irradiation reduces AIRE-expressing mTECs and a unique Ccl25+ TSA-high mTEC cluster, altering mTEC heterogeneity and potentially impairing T cell self-tolerance.

TCR Repertoire Analysis of CD4-Positive T Cells from Blood and an Affected Organ in an Autoimmune Mouse Model

This study examines TCR repertoires in CD4+ T cells from blood and stomachs of AIRE KO mice to correlate TCR diversity with autoimmune symptom variation and organ-specific disease manifestations.

Integrative analysis of scRNAs-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator

The paper identifies transit-amplifying thymic epithelial cells expressing Aire and CD80 through integrative scRNA-seq and scATAC-seq analysis.