Y. Maruyama

Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity

This study identifies C15ORF48 as a mitochondrial protein that induces stress-independent autophagy, reducing oxidative stress and autoimmunity in thymic epithelial cells.

Pseudoirreversible inhibition elicits persistent efficacy of a sphigosine-1-phosphate receptor-1 antagonist

This study identifies KSI-6666 as a pseudoirreversible S1PR1 antagonist that suppresses inflammation through interaction with a methionine residue.

Acute irradiation alters the heterogeneity among medullary thymic epithelial cells 2

This study shows acute irradiation reduces AIRE-expressing mTECs and a unique Ccl25+ TSA-high mTEC cluster, altering mTEC heterogeneity and potentially impairing T cell self-tolerance.

TCR Repertoire Analysis of CD4-Positive T Cells from Blood and an Affected Organ in an Autoimmune Mouse Model

This study examines TCR repertoires in CD4+ T cells from blood and stomachs of AIRE KO mice to correlate TCR diversity with autoimmune symptom variation and organ-specific disease manifestations.

Neutralizing antibody levels and epidemiological information of patients with breakthrough COVID-19 infection in Toyama, Japan

This study examines neutralizing antibody levels and epidemiological data of patients with breakthrough COVID-19 infections in Toyama, Japan, finding that Omicron BA.1 variants show minimal neutralization despite prior vaccination.

Analysis of IGHA1 and other salivary proteins post half marathon in female participants

This study examines changes in salivary proteins, including IGHA1, in female participants before and after a half marathon, finding suppressed antimicrobial proteins and positive correlations among stress markers.

Oral administration of S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and accelerates recovery from clinical aspects of COVID-19

This study shows that oral S-217622 reduces SARS-CoV-2 viral load and improves recovery in hamsters, with activity against multiple variants.

Discovery of S-217622, a Non-Covalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19

This paper describes the discovery of S-217622, an oral non-covalent SARS-CoV-2 3CL protease inhibitor showing antiviral activity and favorable pharmacokinetics in preclinical studies.

Coupled yawing and orbital rotation in kinesin motility revealed by polarization measurement of gold nanorods

This study uses gold nanorods to measure rotational motion in kinesin motors, revealing biaxial rotation that aids in navigating obstacles.

Microplastic pollution of commercial fishes from coastal and offshore waters, Japan

The paper examines microplastic contamination in commercial fish from coastal and offshore waters near Kyushu, Japan, finding higher prevalence and larger sizes in pelagic species compared to demersal ones.

Integrative analysis of scRNAs-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator

The paper identifies transit-amplifying thymic epithelial cells expressing Aire and CD80 through integrative scRNA-seq and scATAC-seq analysis.

Streptococcal phosphotransferase system imports unsaturated hyaluronan disaccharide derived from host extracellular matrices

This paper identifies the streptococcal phosphotransferase system (PTS) as the importer of unsaturated hyaluronan disaccharide, a fragmented form of host extracellular matrix glycosaminoglycan.

Clearance of senescent decidual cells by uterine natural killer cells drives endometrial remodeling during the window of implantation