K. Horie

Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity

This study identifies C15ORF48 as a mitochondrial protein that induces stress-independent autophagy, reducing oxidative stress and autoimmunity in thymic epithelial cells.

Pseudoirreversible inhibition elicits persistent efficacy of a sphigosine-1-phosphate receptor-1 antagonist

This study identifies KSI-6666 as a pseudoirreversible S1PR1 antagonist that suppresses inflammation through interaction with a methionine residue.

Acute irradiation alters the heterogeneity among medullary thymic epithelial cells 2

This study shows acute irradiation reduces AIRE-expressing mTECs and a unique Ccl25+ TSA-high mTEC cluster, altering mTEC heterogeneity and potentially impairing T cell self-tolerance.

TCR Repertoire Analysis of CD4-Positive T Cells from Blood and an Affected Organ in an Autoimmune Mouse Model

This study examines TCR repertoires in CD4+ T cells from blood and stomachs of AIRE KO mice to correlate TCR diversity with autoimmune symptom variation and organ-specific disease manifestations.

Origin, Prospective Identification, and Function of Circulating Endothelial Colony Forming Cells in Mouse and Human

This study identifies the origin and function of circulating endothelial colony forming cells (C-ECFCs) in mice and humans, showing they arise from tissue-resident ECFCs and have vasculogenic potential.

Integrative analysis of scRNAs-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator

The paper identifies transit-amplifying thymic epithelial cells expressing Aire and CD80 through integrative scRNA-seq and scATAC-seq analysis.

Helping Behavior in Prairie Voles: A Model of Empathy and the Importance of Oxytocin

This study shows prairie voles learn to help distressed conspecifics by opening a door, and oxytocin is necessary for this behavior, with no sex differences observed.