T. J. Smith

Adaptation to skin mycobiota promotes antibiotic tolerance in Staphylococcus aureus

This study shows that Malassezia sympodialis reduces Staphylococcus aureus colonization on human skin and identifies Rel variants that confer antibiotic tolerance in response to fungal antagonism.

Reconstitution of a Biofilm Adhesin System from a Sulfate-Reducing Bacterium in Pseudomonas fluorescens

This study reconstitutes a biofilm adhesin system from Desulfovibrio vulgaris in Pseudomonas fluorescens, showing that DvhA's N-terminal fragment is regulated by DvhG/DvhD and c-di-GMP levels.

Conserved 5-methyluridine tRNA modification modulates ribosome translocation

This study identifies m5U54 as a conserved tRNA modification that modulates ribosome translocation and tRNA maturation.

Mitigating a TDP-43 proteinopathy by targeting ataxin-2 using RNA-targeting CRISPR effector proteins

This study uses RNA-targeting CRISPR effector proteins to reduce TDP-43 pathology by targeting ataxin-2 in a mouse model, improving function and survival.

GATA1 knockout in human pluripotent stem cells generates enhanced neutrophils to investigate extracellular trap formation

This study generates GATA1 knockout human pluripotent stem cell-derived neutrophils that form extracellular traps, improving models for studying NET formation and drug screening.

A mucin-regulated adhesin determines the intestinal biogeography and inflammatory character of a bacterial symbiont.

This study identifies a mucin-binding adhesin that regulates bacterial colonization and inflammation in the gut by sensing mucin-associated glycans.

Disaggregation as an interaction mechanism among intestinal bacteria

This study shows that bacterial species in the zebrafish gut compete by dissolving aggregates, and multi-species communities can stabilize this interaction.

Secreted Aeromonas GlcNAc binding protein GbpA stimulates epithelial cell proliferation in the zebrafish intestine

This study identifies a secreted Aeromonas protein, GbpA, that stimulates intestinal epithelial cell proliferation in zebrafish, suggesting a role in host-bacterial coexistence.

Methylated guanosine and uridine modifications in S. cerevisiae mRNAs modulate translation elongation

This study identifies and quantifies new mRNA modifications in S. cerevisiae and shows how they affect translation elongation.

Murine norovirus capsid plasticity - Glycochenodeoxycholic acid stabilizes P domain dimers and triggers escape from antibody recognition

This paper investigates how GCDCA stabilizes MNV P-domain dimers, leading to structural changes that enable immune escape by preventing antibody recognition.

Evidence for nutrient-dependent regulation of the COPII coat by O-GlcNAcylation

The paper identifies O-GlcNAcylation sites on COPII components and shows their potential role in nutrient-sensitive pathway regulation.

MapA, a second large RTX adhesin, contributes to biofilm formation by Pseudomonas fluorescens

The paper identifies MapA, a second RTX adhesin in Pseudomonas fluorescens, which contributes to biofilm formation under specific conditions, with regulation distinct from LapA.

Coopting the Lap system of Pseudomonas fluorescens to reversibly customize bacterial cell surfaces

This study engineers the Lap system of Pseudomonas fluorescens to reversibly display protein cargo on cell surfaces and control its release in response to c-di-GMP levels.

Ligand-Mediated Biofilm Formation via Enhanced Physical Interaction Between a Diguanylate Cyclase and Its Receptor

This paper shows that the DGC GcbC enhances c-di-GMP synthesis and biofilm formation through ligand-mediated interaction with its receptor LapD, with citrate increasing this interaction.