J. Bai

The absence of collagen VI reduces systolic function but paradoxically increases Ca2+ release in the rat heart

This study shows that collagen VI deficiency in rats reduces systolic function but increases Ca2+ release in cardiomyocytes, suggesting a role in Ca2+ signaling regulation.

Eco-evolutionary Guided Pathomic Analysis to Predict DCIS Upstaging

This study uses ecological analysis of hypoxia and acidosis biomarkers to improve prediction of DCIS upstaging by identifying habitat-based metabolic phenotypes and spatial niches.

Climate change has desynchronized insect and vegetation phenologies across Europe

The paper examines phenological shifts in European vegetation and herbivorous insects over 34 years, finding that 61.2% have become asynchronous, with vegetation advancing faster than insects.

AP-1 regulates heterogeneous cellular dormancy in TNBC

The paper identifies heterogeneous subpopulations of slow-cycling cells in TNBC and shows AP-1, particularly the JunB subunit, regulates dormancy and drug resistance.

Thiolation-Based Protein-Protein Hydrogels for Improved Wound Healing

This paper develops protein-protein hydrogels using thiolation and Ag-S bonding to enhance wound healing properties in both diabetic and UV-burn models.

Identification of Determinants that Allow Maintenance of High-Level Fluoroquinolone Resistance in Acinetobacter baumannii

The paper identifies proteins essential for maintaining fitness in Acinetobacter baumannii strains overexpressing RND efflux pumps, highlighting the role of outer membrane integrity and compensatory mechanisms.

Nifuroxazide Suppresses PD-L1 Expression and Enhances the Efficacy of Radiotherapy in Hepatocellular Carcinoma

This study shows nifuroxazide enhances radiotherapy in HCC by reducing PD-L1 expression and improving tumor response.

snoRNA-guided tRNA 2'-O-methylation controls codon-biased gene expression and cellular states

A Quantitative Analysis of Locomotor Patterns in Developing C. elegans

This study quantitatively analyzes locomotor patterns in developing C. elegans, revealing distinct gaits and coordination development across life stages.

GLI1 facilitates rheumatoid arthritis by collaborative regulation of DNA methyltransferases

This study shows GLI1 promotes rheumatoid arthritis by regulating DNA methyltransferases, leading to M1 macrophage polarization and osteoclast activation, and suggests GLI1 inhibitors as potential treatments.

Genome-wide phage susceptibility analysis in Acinetobacter baumannii reveals capsule modulation strategies that determine phage infectivity

This study identifies capsule modulation strategies in Acinetobacter baumannii that determine phage infectivity using Tn-seq and genetic analysis.

Caveolae promote successful abscission by controlling intercellular bridge tension during cytokinesis

The paper shows caveolae reduce intercellular bridge tension during cytokinesis, enabling ESCRT-III assembly and successful abscission.

Chemical Reversible Crosslinking Enables Measurement of RNA 3D Distances and Alternative Conformations in Cells

This paper introduces SHARC, a method to measure RNA 3D distances and alternative conformations in cells, revealing RNA structures and improving 3D modeling.

SCARECROW maintains the stem cell niche in Arabidopsis root by ensuring telomere integrity

This study identifies SCARECROW's role in maintaining telomere integrity and genome stability in Arabidopsis root stem cells through regulation of TEN1 and related factors.

The endophilin curvature-sensitive motif requires electrostatic guidance to recycle synaptic vesicles in vivo

This study shows that endophilin's curvature-sensitive motif requires electrostatic guidance for synaptic vesicle recycling, and that altering this property can restore function in non-functional chimeras.

Bioimage postprocessing based on discrete wavelet transform and Lucy-Richardson deconvolution methods

This paper improves image resolution and signal-to-noise ratio in live cell imaging using a combination of discrete wavelet transform and Lucy-Richardson deconvolution.

All-Flesh Tomato Regulated by Reduced Dosage of AFF Provides New Insights into Berry Fruit Evolution

The study identifies a 416-bp deletion in the AFF gene's promoter that reduces its expression, leading to all-flesh tomato fruits and providing insights into berry fruit evolution.

Evidence for nutrient-dependent regulation of the COPII coat by O-GlcNAcylation

The paper identifies O-GlcNAcylation sites on COPII components and shows their potential role in nutrient-sensitive pathway regulation.

The Phaeodactylum tricornutum Diaminopimelate Decarboxylase was Acquired via Horizontal Gene Transfer from Bacteria and Displays Substrate Promiscuity

This paper identifies a horizontally transferred DAPDC gene in Phaeodactylum tricornutum that exhibits substrate promiscuity in lysine biosynthesis.

Essential gene analysis in Acinetobacter baumannii by high-density transposon mutagenesis and CRISPR interference

This study identifies essential genes in Acinetobacter baumannii using transposon mutagenesis and a CRISPRi system, revealing new factors and conditionally essential processes.

Dynamic Mechanical Cue Facilitate Collective Responses of Crowded Cell Population

This study shows that dynamic mechanical cues in crowded cell populations enhance collective responses in NF-κB signaling and nuclear shape fluctuations through mechano-signaling feedback loops.

Click-ExM enables expansion microscopy for all biomolecules

Click-ExM expands super-resolution imaging to all biomolecules by integrating click-labeling into expansion microscopy.

Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Endosomal Sensing by Dendritic Cells in Psoriasis

This study shows that excessive polyamine production in keratinocytes drives self-RNA sensing by dendritic cells, contributing to psoriasis inflammation.

Calcium induced calcium release in proximity to hair cell BK channels revealed by PKA activation

The paper shows that PKA activation enhances BK currents in chicken hair cells by increasing Ca2+ concentrations via CICR near BK channels.

Expression, Purification, and Functional Reconstitution of 19F-labeled Cytochrome b5 in Peptide Nanodiscs for NMR Studies

This study expresses, purifies, and functionally reconstitutes 19F-labeled cytochrome b5 in peptide nanodiscs to enable NMR studies of its transmembrane domain interactions with CYP2B4.

A mechanism coordinating root elongation, endodermal differentiation, redox homeostasis and response

This study identifies SCR's role in promoting root growth by enhancing cell elongation and maintaining redox homeostasis through suppression of oxidative stress response.

Drought Resistance of 10 Ground Cover Seedling Species during Roof Greening

This study evaluates drought resistance of 10 ground cover seedling species for roof greening by measuring physiological and biochemical responses under controlled drought stress scenarios.

Timing and causes of the distribution pattern of Oncomelania hupensis estimated by molecular and geologic data

This study estimates the timing and causes of the distribution pattern of Oncomelania hupensis subspecies using molecular data and geological events, finding that tectonic and climatic factors drove divergence at specific times.

5-hydroxy-4′-nitro-7-propionyloxy-genistein inhibited invasion and metastasis via inactivating wnt/β-catenin signal pathway in human endometrial carcinoma JEC cells

This study investigates the anticancer effects of HNPG on JEC cells, finding it inhibits proliferation, invasion, and metastasis by inactivating the Wnt/β-catenin pathway.