J. Henriksson

The CD4 T cell epigenetic JUNB+ state is associated with proliferation and exhaustion

The paper identifies a JUNB+ epigenetic state in CD4 T cells associated with proliferation, exhaustion, and memory formation, and develops a new machine learning tool to analyze its regulation.

A community-curated, global atlas of Bacillus cereus sensu lato genomes for epidemiological surveillance

The paper develops BTyperDB, a global atlas of Bacillus cereus sensu lato genomes, to improve pathogen surveillance and identify emerging lineages.

Avoidance of hydrogen sulfide is modulated by external and internal states in C. elegans

This study investigates how C. elegans modulates its avoidance response to hydrogen sulfide through environmental and internal factors, revealing HIF-1 signaling and ROS dynamics as key regulators.

Single-cell profiling uncovers regulatory programs of pathogenic Th2 cells in allergic asthma

This study uses scRNA-seq to identify two distinct subsets of pathogenic Th2 cells in allergic asthma and establishes an in vitro model to study their regulation.

Telomemore enables single-cell analysis of cell cycle and chromatin condensation

Telomemore quantifies subtelomeric reads from single-cell data to assess chromatin condensation and complements cell cycle analysis in single-cell RNA-seq.

IL-17 activation undermines longevity and stress tolerance by inhibiting a protective transcriptional network

This study shows that IL-17 overactivation in C. elegans reduces lifespan and stress tolerance by inhibiting a protective transcriptional network involving NHR-49 and MDT-15.

scDual-Seq of Toxoplasma gondii-infected mouse bone marrow-derived dendritic cells reveals host cell heterogeneity and differential infection dynamics

The paper uses Dual-scSeq to analyze T. gondii-infected BMDCs, revealing differential infection dynamics and host-parasite gene interactions.

Single-cell transcriptomics to define Plasmodium falciparum stage-transition in the mosquito midgut

This study uses single-cell transcriptomics to analyze Plasmodium falciparum development in the mosquito midgut, identifying transcriptional trajectories and stress responses, including genes encoding intrinsically disordered proteins.

Type I interferon shapes brain distribution and tropism of tick-borne flavivirus

The paper uses multimodal imaging and single nuclei RNA-sequencing to study how type I interferon affects viral tropism in the brain during flavivirus infection in mice.

Regulation of Decay Accelerating Factor primes human germinal center B cells for phagocytosis

This study shows that downregulation of DAF on B cells primes them for phagocytosis before apoptosis in germinal centers.

Rora regulates activated T helper cells during inflammation

This study investigates Rora's role in CD4+ T cells during inflammation, finding it regulates lung inflammation and is controlled by IL-33 and CCL7.

Unbiased classification of mosquito blood cells by single-cell genomics and high-content imaging

The paper uses single-cell genomics and imaging to classify mosquito blood cells, revealing transcriptional signatures and challenges to current morphology-based classification.

The IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation

This study identifies XBP1 target genes and shows the IRE1a-XBP1 pathway resolves secretory stress and promotes Th2 cell proliferation and cytokine regulation.