IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques
C. E. Nelson, T. W. Foreman, K. D. Kauffman, S. Sakai, S. T. Gould, J. D. Fleegle, F. Gomez, NIAID/DIR Tuberculosis Imaging Program, C. Le Nouen, X. Liu, T. L. Burdette, N. L. Garza, B. A. P. Lafont, K. Brooks, C. S. L. Arlehamn, , D. L. Barber
This study examines the roles of IFNγ and IL-10 in SARS-CoV-2 infection of rhesus macaques, finding IL-10 suppresses T cell expansion but promotes tissue-resident memory cell formation.
bioRxiv · Sep 13, 2022Immunology