Author

J. D. Fleegle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:rat· 2 Assay:CITE-seq· 1 Research Focus:development & morphogenesis· 1 Organism:non-human primate· 1

Frequent Co-Authors

D. L. Barber· 3 shared F. Gomez· 3 shared K. D. Kauffman· 3 shared L. E. Via· 3 shared A. Sette· 2 shared C. E. Nelson· 2 shared C. S. Lindestam Arlehamn· 2 shared D. E. Dorosky· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

D. L. Barber

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques

C. E. Nelson, T. W. Foreman, K. D. Kauffman, S. Sakai, S. T. Gould, J. D. Fleegle, F. Gomez, NIAID/DIR Tuberculosis Imaging Program, C. Le Nouen, X. Liu, T. L. Burdette, N. L. Garza, B. A. P. Lafont, K. Brooks, C. S. L. Arlehamn, , D. L. Barber

This study examines the roles of IFNγ and IL-10 in SARS-CoV-2 infection of rhesus macaques, finding IL-10 suppresses T cell expansion but promotes tissue-resident memory cell formation.

bioRxiv · Sep 13, 2022Immunology

CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection

T. W. Foreman, C. E. Nelson, K. D. Kauffman, N. E. Lora, C. L. Vinhaes, D. E. Dorosky, S. W. Sakai, F. Gomez, J. D. Fleegle, M. Parham, S. R. Perera, C. S. Lindestam Arlehamn, A. Sette, Tuberculosis Imaging Program, J. M. Brenchley, , D. L. Barber

This study shows that acute SIV co-infection rapidly depletes CD4 T cells from tuberculosis granulomas before systemic CD4 T cell loss or disease reactivation.

bioRxiv · Dec 17, 2021Immunology

Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates

S. Sakai, N. E. Lora, K. D. Kauffman, D. E. Dorosky, S. Oh, S. Namasivayam, F. Gomez, J. D. Fleegle, C. S. Lindestam Arlehamn, A. Sher, G. J. Freeman, L. E. Via, C. E. Barry, D. L. Barber

This study shows that 5-OP-RU treatment of M. tuberculosis-infected rhesus macaques leads to MAIT cell dysfunction rather than expansion, with upregulated PD-1 and loss of cytokine production.

bioRxiv · Jan 29, 2021Immunology