Multiplexed screen identifies a Pseudomonas aeruginosa-specific small molecule targeting the outer membrane protein OprH and its interaction with LPS
Bradley E. Poulsen, Thulasi Warrier, Sulyman Barkho, Josephine Bagnall, Keith P. Romano, T. L. White, Xiao Yu, Tomohiko Kawate, Phuong H. Nguyen, Kyra Raines, Kristina M. Ferrara, Aaron J. Golas, Michael G. FitzGerald, Andras Boeszoermenyi, Virendar K. Kaushik, , Deborah Tan Hung
The paper identifies a Pseudomonas aeruginosa-specific small molecule, BRD1401, that targets OprH and disrupts its interaction with LPS, increasing membrane fluidity.
Cell chemical biology · Dec 27, 2024Peer-reviewedMicrobiology