A. Fiebig

Adaptive diversification through structural variation in barley

This study presents a barley pangenome revealing structural variation linked to traits like disease resistance and plant architecture, highlighting its role in adaptive evolution.

Untangling the Role of Pathobionts from Bacteroides Species in Inflammatory Bowel Diseases

This study shows that Bacteroides fragilis from UC patients promotes colitis in genetically susceptible mice, suggesting a role for pathobionts in IBD.

Microbially-catalyzed conjugation of GABA and tyramine to bile acids

The paper identifies bacteria that conjugate GABA and tyramine to bile acids in the human gut and shows these conjugates are present in stool and J-pouch contents.

XRE Transcription Factors Conserved in Caulobacter and {varphi}CbK Modulate Adhesin Development and Phage Production

This study identifies XRE transcription factors in Caulobacter and its phage {varphi}CbK that regulate adhesin development and phage production through heteromeric interactions and gene repression.

The Caulobacter NtrB-NtrC two-component system bridges nitrogen assimilation and cell development

This study investigates the role of the NtrB-NtrC two-component system in Caulobacter nitrogen metabolism and development, revealing its impact on growth, cell cycle regulation, and polysaccharide synthesis.

Bile acid fitness determinants of a Bacteroides fragilis isolate from a human pouchitis patient

This study identifies genes and pathways in B. fragilis that affect its fitness in bile acids, using a barcoded mutant library and transcriptomic analysis.

Cross regulation in a three-component cell envelope stress signaling system of Brucella

This study identifies three TCS proteins in Brucella ovis that work together to confer resistance to cell envelope stressors and support intracellular replication.

Genomic resources for a historical collection of cultivated two-row European spring barley genotypes.

The paper provides genomic and phenotypic data for 209 historical two-row spring barley cultivars, enabling downstream analyses such as GWAS and expression associations.

A cryptic transcription factor regulates Caulobacter adhesin development

This paper identifies RtrC, a transcription factor regulated by the adhesion TCS system in Caulobacter crescentus, which represses hfiA to activate holdfast development and influences biofilm formation.

Dynamic genetic adaptation of Bacteroides thetaiotaomicron murine gut colonization

This study tracks genetic and metabolic changes in Bacteroides thetaiotaomicron during gut colonization, showing shifting gene usage and highlighting the importance of carbohydrate metabolism for long-term persistence.

The ChvG-ChvI and NtrY-NtrX two-component systems coordinately regulate growth of Caulobacter crescentus

This paper identifies regulatory links between the ChvG-ChvI and NtrY-NtrX two-component systems in Caulobacter crescentus, showing their coordinated role in growth and cell envelope maintenance.

Flagellar perturbations activate adhesion through two distinct pathways in Caulobacter crescentus

This study identifies two distinct pathways by which flagellar perturbations in Caulobacter crescentus enhance adhesion through holdfast production.

Brucella ovis cysteine biosynthesis contributes to peroxide stress survival and fitness in the intracellular niche

This study identifies cysteine biosynthesis as critical for Brucella ovis survival under peroxide stress in the intracellular niche, revealing redundancy in CysK enzymes.

Quantification of Brucella abortus population structure in a natural host

This study quantifies Brucella abortus population structure in cattle using barcoded strains, revealing a severe bottleneck limiting colonization of lymph nodes.

Feedback control of a two-component signaling system by an Fe-S-binding receiver domain

This paper identifies an Fe-S-binding receiver domain in FixT that inhibits FixL autophosphorylation and regulates heme homeostasis in Caulobacter crescentus.

A carbonic anhydrase pseudogene sensitizes select Brucella lineages to low CO2 tension

This study shows that pseudogenes in the carbonic anhydrase gene bcaA make Brucella ovis and B. abortus more sensitive to low CO2 tension, affecting their growth and virulence.

Regulation of the Erythrobacter litoralis DSM 8509 general stress response by visible light

This study identifies three HWE kinases that regulate GSR transcription in Erythrobacter litoralis, showing visible light and LovK influence GSR through a phosphorylation-dependent mechanism.

The role of Caulobacter cell surface structures in colonization of the air-liquid interface

This study defines the role of cell surface structures in Caulobacter crescentus colonization of the air-liquid interface, showing that the holdfast enables partitioning of non-motile cells to this niche.

Composition of the holdfast polysaccharide from Caulobacter crescentus

This study isolates and characterizes the holdfast polysaccharide from Caulobacter crescentus, identifying its monosaccharide composition and structural features.

Brucella periplasmic protein EipB is a molecular determinant of cell envelope integrity and virulence

This study identifies EipB as a conserved periplasmic protein in Brucella that maintains cell envelope integrity and contributes to virulence, with structural and genetic interactions with TtpA.

Regulation of bacterial surface attachment by a network of sensory transduction proteins

This study identifies a multi-gene network regulating surface attachment in Caulobacter crescentus by controlling hfiA transcription in response to environmental cues.

A genome-wide analysis of adhesion in Caulobacter crescentus identifies new regulatory and biosynthetic components for holdfast assembly

This study identifies new genes involved in holdfast biosynthesis and attachment in Caulobacter crescentus through a genome-wide screen.

Periplasmic protein EipA determines envelope stress resistance and virulence in Brucella abortus

This study identifies EipA as a periplasmic protein in Brucella abortus that enhances envelope stress resistance and virulence by maintaining cell envelope integrity and influencing cell division.

Genome-scale fitness profile of Caulobacter crescentus grown in natural freshwater

This study uses transposon sequencing to assess gene fitness in Caulobacter crescentus grown in natural freshwater, revealing environmental interactions and gene function differences compared to lab media.

Molecular control of gene expression by Brucella BaaR, an IclR-family repressor

This study characterizes BaaR, an IclR-family repressor in Brucella abortus, showing it represses carboxylic acid oxidation operons and is activated by specific organic molecules.

Gene network analysis identifies a central post-transcriptional regulator of cellular stress survival

The paper identifies GsrN as a key post-transcriptional regulator of stress survival in Caulobacter crescentus using network analysis of transcription data.