Author

R. Trenker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

D. Diwanji· 3 shared K. A. Verba· 2 shared N. Jura· 2 shared A. A. Anand· 1 shared A. F. Brilot· 1 shared A. M. Smith· 1 shared A. N. Rizo· 1 shared B. Barsi-Rhyne· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

D. Diwanji

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Author profile →

3 papers

Recent·Most cited

Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation

R. Trenker, D. Diwanji, T. Bingham, K. A. Verba, N. Jura

This study reports cryo-EM structures of HER2/HER4 heterodimers and HER4 homodimers bound to different ligands, revealing structural dynamics and glycan contributions to receptor activation.

bioRxiv · Oct 6, 2023Biochemistry

Structures of the active HER2/HER3 receptor complex reveal dynamics at the dimerization interface induced by binding of a single ligand

D. Diwanji, R. Trenker, T. M. Thaker, F. Wang, D. A. Agard, K. A. Verba, N. Jura

This study presents cryo-EM structures of the HER2/HER3 receptor complex bound to NRG1β, revealing conformational dynamics at the dimerization interface and how mutations and therapeutics interact with this interface.

bioRxiv · May 3, 2021 · PreprintBiophysics

An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation

M. Schoof, B. Faust, R. A. Saunders, S. Sangwan, V. V. Rezelj, N. Hoppe, M. Boone, C. Billesboelle, C. Puchades, C. M. Azumaya, H. T. Kratochvil, M. Zimanyi, I. Deshpande, J. Liang, S. Dickinson, , Barile-H

This paper develops a potent synthetic nanobody that neutralizes SARS-CoV-2 by locking its Spike protein in an inactive conformation, enabling aerosol delivery as a prophylactic or therapeutic agent.

bioRxiv · Aug 8, 2020Biochemistry