N. Jura

Protein-protein interactions with G3BPs drive stress granule condensation and gene expression changes under cellular stress

The paper identifies key residues in G3BPs that drive stress granule formation and gene expression changes under cellular stress, with G3BP2B showing specific roles in ER stress.

Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation

This study reports cryo-EM structures of HER2/HER4 heterodimers and HER4 homodimers bound to different ligands, revealing structural dynamics and glycan contributions to receptor activation.

Structural insights into regulation of the PEAK3 scaffold by 14-3-3

This paper reports the cryo-EM structure of PEAK3 pseudokinase in complex with 14-3-3, revealing an asymmetric binding mechanism and identifying Protein Kinase D as a regulator.

Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

This study identifies that the B.1.1.7 SARS-CoV-2 variant enhances innate immune evasion through increased Orf9b and Orf6 expression and activity.

Structures of the active HER2/HER3 receptor complex reveal dynamics at the dimerization interface induced by binding of a single ligand

This study presents cryo-EM structures of the HER2/HER3 receptor complex bound to NRG1β, revealing conformational dynamics at the dimerization interface and how mutations and therapeutics interact with this interface.

CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids

This study identifies CNPY4 as a negative regulator of the Hedgehog pathway by modulating membrane sterol lipid levels, revealing a new mechanism of pathway regulation.

The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia

This paper reports the crystal structure of a cardiac calsequestrin filament and identifies mutations that disrupt filament formation, linking them to arrhythmia.