T. Matsuzaki

Transcriptional drift in aging cells: A global de-controller

The paper identifies transcriptional drift in aging C. elegans worms, showing upregulated sensory proteins and downregulated growth/metabolism genes, and proposes a mechanistic model involving ligand binding.

Engineered Active Zymogen of Microbial Transglutaminase

This paper designs an engineered active zymogen of microbial transglutaminase (EzMTG) that exhibits cross-linking activity without requiring proteolysis, and identifies mutations that balance binding affinity and catalytic activity.

A novel plasmid-based experimental system in Saccharomyces cerevisiae that enables the introduction of 10 different plasmids into cells

This paper introduces a yeast-based system allowing the co-expression of up to 20 different proteins by maintaining 10 plasmids in auxotrophic {Delta}10 strains.

Robust capability of renal tubule fatty acid uptake from apical and basolateral membranes in physiology and disease

This study investigates fatty acid uptake by renal tubule epithelial cells in mice, showing uptake from both blood and urine, and storage as neutral lipids, with CD36 playing a key role in blood-derived uptake.

A machine learning model that emulates experts decision making in vancomycin initial dose planning

This study develops a machine learning model to emulate expert decision-making for vancomycin initial dosing, achieving comparable therapeutic outcomes to expert-recommended regimens.

Micromanipulation of amyloplasts with optical tweezers in Arabidopsis stems

The paper uses optical tweezers to manipulate amyloplasts in Arabidopsis stems and observes their interactions with vacuolar membranes, revealing biophysical responses to mechanical stimuli.