R. Tanaka

A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24

This paper identifies a heterocyclic compound, HT-7, that inhibits HIV-1 release by increasing cell surface BST2 expression with minimal cellular toxicity.

Glutathione supersulphide regulates T-cell receptor signalling

This study shows that glutathione supersulphide regulates T-cell receptor signalling by interacting with the CD3ε chain, affecting TCR activation and inflammation.

Liver fibrosis uncouples tumor control from survival after multikinase inhibitor immunotherapy in hepatocellular carcinoma

Liver fibrosis limits the survival benefit of multikinase inhibitor immunotherapy in hepatocellular carcinoma by promoting innate immune-mediated hepatotoxicity despite preserved tumor control.

Expression of transcription factors KLF2 and KLF4 is induced by the mammalian Golgi stress response

The paper identifies KLF2 and KLF4 as transcription factors induced by PG-type Golgi stress and involved in regulating proteoglycan pathways.

Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liver

This study shows that Gas6, secreted by intestinal macrophages, prevents K. pneumoniae translocation to the liver in mice, but its reduction in aging allows bacterial invasion and systemic infection.

ULTRAFAST STRUCTURAL CHANGES DIRECT THE FIRST MOLECULAR EVENTS OF VISION

This study uses ultrafast crystallography to reveal how photoactivated retinal initiates structural changes in rhodopsin, leading to GPCR activation and vision.

Collaborative hunting in artificial agents with deep reinforcement learning

This study shows that collaborative hunting in artificial agents can emerge through simple decision rules using deep reinforcement learning, without requiring complex cognitive processes.

Robust capability of renal tubule fatty acid uptake from apical and basolateral membranes in physiology and disease

This study investigates fatty acid uptake by renal tubule epithelial cells in mice, showing uptake from both blood and urine, and storage as neutral lipids, with CD36 playing a key role in blood-derived uptake.

Phylogeny analysis of whole protein-coding genes in metagenomic data detected an environmental gradient for the microbiota

The paper develops MPASS to analyze metagenomic data and identifies environmental gradients influencing microbiota composition.

Mapping Protein Dynamics at High-Resolution with Temperature-Jump X-ray Crystallography

This study uses temperature-jump X-ray crystallography to observe atomic-scale protein motions in lysozyme, showing how vibrations evolve into functional movements and how inhibitors alter these dynamics.

Glycosylphosphatidylinositol-anchoring is required for the proper transport and glycosylation of classical arabinogalactan protein precursor in tobacco BY-2 cells

This study shows that GPI-anchoring is essential for the correct transport and glycosylation of an AGP precursor in tobacco cells.

High-resolution Crystal Structures of Transient Intermediates in the Phytochrome Photocycle

The paper captures high-resolution crystal structures of transient phytochrome intermediates to elucidate the structural changes during the Pr-to-Pfr photocycle.

Disentangling primer interactions improves SARS-CoV-2 genome sequencing by the ARTIC Network's multiplex PCR

The paper improves SARS-CoV-2 genome sequencing by modifying the ARTIC Network's primer set to reduce primer dimer interactions, enhancing coverage in low viral load samples.

The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser

This study captures the structural changes in bacterial phytochrome proteins after light exposure using femtosecond X-ray crystallography, revealing key molecular movements involved in the photoresponse.

Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals

This study compares serial X-ray crystallography and MicroED for determining structures from small macromolecular crystals, highlighting their strengths and challenges.

Atomic resolution structure of serine protease proteinase K at ambient temperature

The paper reports an atomic resolution structure of proteinase K at ambient temperature using serial femtosecond crystallography, revealing hydrogen atoms, water molecules, and side-chain conformations.