Author

T. N. Zech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

E. Hargreaves· 2 shared A. Al-Malki· 1 shared A. Charles-Orszag· 1 shared A. D. Jenks· 1 shared A. S. Staszewski· 1 shared A. Tsalikis· 1 shared B. E. TANOS· 1 shared D. Newman· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

E. Hargreaves

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Dock-and-lock binding of SxIP ligands is required for stable and selective EB1 interactions.

T. Almeida, E. Hargreaves, T. N. Zech, I. Barsukov

The paper shows that the SxIP motif binds EBH with low affinity, but full interaction requires post-SxIP residues, leading to a nanomolar affinity and enhanced recruitment to microtubule plus ends.

bioRxiv · Feb 27, 2024Biochemistry

Dysregulated SASS6 expression promotes increased ciliogenesis and cell invasion phenotypes

E. Hargreaves, A. D. Jenks, A. S. Staszewski, A. Tsalikis, R. Bodoque Villar, M. Arias Garcia, Y. Abdi, A. Al-Malki, Y. Yuan, R. Natrajan, S. Haider, T. Iskratsch, W.-J. Wang, S. Godinho, N. J. Palaskas, , B. E. TANOS

This study shows that overexpression of SAS-6 promotes ciliogenesis and cell invasion through YAP/TAZ pathway activation, linked to poor cancer prognosis.

bioRxiv · Jan 29, 2024 · PreprintCell Biology

3D matrix adhesion composition facilitates nuclear force coupling to drive invasive cell migration

D. Newman, L. Young, T. Waring, L. Brown, K. Wolanska, E. MacDonald, A. Charles-Orszag, P. Caswell, T. Sakuma, T. Yamamoto, L. M. Machesky, M. Morgan, T. N. Zech

This study identifies a 3D matrix adhesion complex involving β-PIX and Myo18A that drives invasive cell migration by coupling nuclear force transmission to protrusion dynamics.

bioRxiv · May 17, 2021 · PreprintCell Biology