Author

I. Barsukov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Assay:proteomics· 3 Research Focus:development & morphogenesis· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. Ballestrem· 2 shared D. Critchley· 2 shared P. Atherton· 2 shared A. Carisey· 1 shared A. Datye· 1 shared A. Gilmore· 1 shared A. Kumar· 1 shared B. T. Goult· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

C. Ballestrem

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Author profile →

5 papers

Recent·Most cited

Dock-and-lock binding of SxIP ligands is required for stable and selective EB1 interactions.

T. Almeida, E. Hargreaves, T. N. Zech, I. Barsukov

The paper shows that the SxIP motif binds EBH with low affinity, but full interaction requires post-SxIP residues, leading to a nanomolar affinity and enhanced recruitment to microtubule plus ends.

bioRxiv · Feb 27, 2024Biochemistry

Mechanosensing through talin 1 contributes to tissue mechanical homeostasis

M. V. Chanduri, A. Kumar, D. Weiss, N. Emuna, I. Barsukov, M. Shi, K. Tanaka, X. Wang, A. Datye, J. Kanyo, F. Collin, T. Lam, U. D. Schwarz, S. Bai, T. Nottoli, , M. A. Schwartz

This study shows that mutations in talin1 alter cellular stiffness sensing, leading to changes in ECM mechanical properties and aortic compliance.

bioRxiv · Sep 3, 2023 · PreprintCell Biology

Tensin3 interaction with talin drives formationof fibronectin-associated fibrillar adhesions

P. Atherton, R. Konstantinou, S. P. Neo, E. Wang, E. Balloi, M. Ptushkina, H. Bennett, K. Clark, J. Gunaratne, D. Critchley, I. Barsukov, E. Manser, C. Ballestrem

This study identifies tensin3's interaction with talin as essential for fibronectin fibrillogenesis and integrin-associated fibrillar adhesions.

bioRxiv · Jul 16, 2021Cell Biology

Force-independent interactions of talin and vinculin govern integrin-mediated mechanotransduction

P. Atherton, F. Lausecker, A. Carisey, A. Gilmore, D. Critchley, I. Barsukov, C. Ballestrem

This study shows that talin and vinculin interact without requiring force, challenging previous models of integrin-mediated mechanotransduction.

bioRxiv · May 7, 2019Cell Biology

New tools for carbohydrate sulphation analysis: Heparan Sulphate 2-O-sulphotranserase (HS2ST) is a target for small molecule protein kinase inhibitors

D. P. Byrne, Y. Li, K. Ramakrishnan, I. Barsukov, E. Yates, C. Eyers, D. Papy-Garcia, S. Chantepie, V. Pagadala, J. Liu, C. Wells, D. Drewry, W. Zuercher, N. Berry, D. Fernig, P. A. Eyers

This paper introduces a new non-radioactive assay for HS2ST activity using a synthetic fluorescent substrate and identifies protein kinase inhibitors that inhibit HS2ST-catalyzed sulphation.

bioRxiv · Apr 6, 2018Biochemistry