T. Sakuma

UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins

This study shows UGGT1 reglucosylation competes with EDEM-mediated degradation of misfolded glycoproteins, influencing ER protein quality control.

Inhibition of OCT4 Binding at the MYCN Locus Induces Neuroblastoma Cell Death Accompanied by Downregulation of Transcripts with High-Open Reading Frame Dominance

This study shows that inhibiting OCT4 binding at the MYCN locus in neuroblastoma cells reduces MYCN activity, leading to cell death through caspase-2 activation and downregulation of high-ORF dominance transcripts.

Frame Editors for Precise, Template-Free Frameshifting

This paper introduces Frame Editors (FEs) that improve CRISPR-Cas9 editing accuracy by inducing controlled frameshifts without templates, reducing random mutations and off-target effects.

Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine

This study develops an oral rhabdoviral vaccine that boosts SARS-CoV-2 immunity in nonhuman primates by enhancing viral tropism through G protein trans-complementation.

3D matrix adhesion composition facilitates nuclear force coupling to drive invasive cell migration

This study identifies a 3D matrix adhesion complex involving β-PIX and Myo18A that drives invasive cell migration by coupling nuclear force transmission to protrusion dynamics.