T. R. Graham

Lipid transport by Candida albicans Dnf2 is required for hyphal growth and virulence

This study shows that the Candida albicans Dnf2 transporter, which moves GlcCer and PC, is essential for hyphal growth and virulence.

An interaction between betaprime-COP and the ArfGAP, Glo3, maintains post-Golgi cargo recycling

This study identifies the interaction between betaprime-COP and Glo3, an ArfGAP, showing it is essential for post-Golgi cargo recycling in yeast.

Ubiquitination drives COPI priming and Golgi SNARE localization

The paper identifies ubiquitin recognition by COPI as essential for Golgi SNARE localization and stabilizing interactions between Arf, COPI, and SNAREs.

Structural basis of the P4B ATPase lipid flippase activity

This study reports the first structure of a P4B ATPase, Neo1, and shows it uses a conserved mechanism for substrate transport similar to dimeric flippases.

Drs2 regulates TRAPPIII in Atg9 transport: exposing the interplay of P4-ATPases and Multisubunit Tethering Complexes

The paper investigates how Drs2 interacts with TRAPPIII to regulate Atg9 transport during selective autophagy, revealing a novel role for P4-ATPases in this process.

Transport mechanism of class-3 P4 ATPase lipid flippases

This study reveals the transport mechanism of class-3 P4 ATPases by analyzing their structure and function, showing conserved lipid-flipping mechanisms and unique features.

Exofacial membrane composition and lipid metabolism regulates plasma membrane P4-ATPase substrate specificity

This study investigates how membrane composition and lipid metabolism influence the substrate specificity of the yeast P4-ATPase Dnf2.

Mammalian retromer is an adaptable scaffold for cargo sorting from endosomes

This study identifies adaptable retromer structures and their role in cargo sorting from endosomes to the TGN or plasma membrane in mammals.

COPI Mediates Recycling Of An Exocytic SNARE From Endosomes By Recognition Of A Ubiquitin Sorting Signal

This study shows COPI mediates recycling of the SNARE Snc1 from early endosomes to the Golgi via recognition of a polyubiquitin sorting signal.