Author

T. Segura

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 9

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 7 Organism:mouse· 5 Research Focus:development & morphogenesis· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:trajectory inference· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 2

Frequent Co-Authors

L. Riley· 4 shared Y. Liu· 4 shared A. Suarez-Arnedo· 3 shared E. Sideris· 3 shared A. R. Anderson· 2 shared K. L. Wilson· 2 shared M. Schneider· 2 shared N. J. Darling· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersBioengineering

L. Riley

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Author profile →

9 papers

Recent·Most cited

Engineering the microstructure and spatial bioactivity of MAP scaffolds in vitro instructs neovascularization in vivo

A. R. Anderson, E. L. P. Caston, L. Riley, L. Nguyen, D. Ntekoumes, S. Gerecht, T. Segura

This study tunes microstructure and bioactivity of MAP scaffolds to guide cell patterning and promote vessel formation in vitro and enhance neovascularization in vivo.

bioRxiv · Nov 1, 2023 · PreprintBioengineering

SDF-1 Bound Heparin Nanoparticles Recruit Progenitor Cells for Their Differentiation and Promotion of Angiogenesis After Stroke

T. Segura, K. L. Wilson, L. A. Onweller, N. I. Joseph, J. David-Bercholz, N. J. Darling

This study develops heparin-norbornene nanoparticles with SDF-1 to recruit progenitor cells and promote angiogenesis after stroke, achieving revascularization in 10 days.

bioRxiv · Jul 5, 2023Bioengineering

Exploring the Role of Spatial Confinement in Immune Cell Recruitment and Regeneration of Skin Wounds

Y. Liu, A. Suarez-Arnedo, E. Caston, L. Riley, M. Schneider, T. Segura

The paper investigates how spatial confinement in MAP scaffolds affects immune cell recruitment and wound healing, finding that larger pores promote a balanced macrophage response and better regeneration.

bioRxiv · Apr 30, 2023Bioengineering

A balance between pro-inflammatory and pro-reparative macrophages is observed in regenerative D-MAPS

Y. Liu, A. Suarez-Arnedo, S. Shetty, M. Schneider, J. H. Collier, T. Segura, Y. Wu

The paper investigates the immunomodulatory effect of D-MAPS and finds a balance between pro-inflammatory and pro-reparative macrophages in regenerative scaffolds.

bioRxiv · Aug 17, 2022Bioengineering

Spatial confinement modulates macrophage response in microporous scaffolds

Y. Liu, A. Suarez-Arnedo, L. Riley, T. Miley, J. Xia, T. Segura

This study investigates how spatial confinement in microporous scaffolds affects macrophage polarization and inflammatory response.

bioRxiv · Aug 16, 2022Bioengineering

Void volume fraction of granular scaffolds

L. Riley, G. Wei, Y. Bao, P. Cheng, K. L. Wilson, Y. Liu, Y. Gong, T. Segura

The paper provides simulated granular scaffolds with known void volume fraction (VVF) to study measurement accuracy and reveals VVF may be unreliable as a descriptor.

bioRxiv · Jun 14, 2022Bioengineering

Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing.

D. R. Griffin, M. M. Archang, C. H. Kuan, W. Weaver, J. S. Weinstein, A. C. Feng, A. Ruccia, E. Sideris, V. Ragkousis, J. Koh, M. V. Plikus, D. Di Carlo, T. Segura, P. O. Scumpia

This study shows that D-peptide crosslinked hydrogels induce adaptive immune responses that promote regenerative wound healing despite faster degradation.

bioRxiv · May 27, 2020Bioengineering

Hyaluronic acid particle hydrogels decrease cerebral atrophy and promote pro-reparative astrocyte/axonal infiltration after ischemic stroke

E. Sideris, A. Yu, J. Chen, S. T. Carmichael, T. Segura

This study shows that HA-MAP hydrogel injection reduces cerebral atrophy and promotes pro-repair astrocyte and axonal infiltration after ischemic stroke.

bioRxiv · Sep 14, 2019 · PreprintBioengineering

Click by Click Microporous Annealed Particle (MAP) Scaffolds

N. J. Darling, W. Xi, E. Sideris, A. R. Anderson, C. Pong, S. T. Carmichael, T. Segura

This paper develops a tunable MAP scaffold using click chemistry to adjust hydrogel rigidity and demonstrates its biocompatibility in an ischemic stroke model.

bioRxiv · Sep 12, 2019Bioengineering