Author

P. Cheng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Bioengineering· 1 Cancer Biology· 1 Immunology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

D. Fenyo· 2 shared H. Li· 2 shared L. Katsnelson· 2 shared T. Davoli· 2 shared X. Zhao· 2 shared Y. Liu· 2 shared A. F. Johnson· 1 shared A. Goldberg· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCell Biology

D. Fenyo

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Novel Curcuphenol Analogues Possess Anti-Metastatic Biologic Activity

S. L. S. Ellis, L. L. Nohara, S. Dada, I. Saranchova, L. Munro, K. B. Choi, E. Garrovillas, C. G. Pfeifer, D. E. Williams, P. Cheng, R. J. Andersen, W. Jefferies

The paper develops water-soluble curcuphenol analogues with improved chemical properties that reverse tumour immune-escape mechanisms, reducing metastatic growth.

bioRxiv · May 15, 2023 · PreprintBiochemistry

KaryoCreate: a new CRISPR-based technology to generate chromosome-specific aneuploidy by targeting human centromeres

N. Bosco, A. Goldberg, A. F. Johnson, X. Zhao, J. C. Mays, P. Cheng, J. J. Bianchi, C. Toscani, L. Katsnelson, D. Annuar, S. Mei, R. E. Faitelson, I. Y. Pesselev, K. S. Mohamed, A. Mermerian, , T. Davoli

KaryoCreate generates chromosome-specific aneuploidy by targeting centromeres with CRISPR, showing it can induce gains or losses of targeted chromosomes in human cells.

bioRxiv · Sep 27, 2022 · PreprintCell Biology

Void volume fraction of granular scaffolds

L. Riley, G. Wei, Y. Bao, P. Cheng, K. L. Wilson, Y. Liu, Y. Gong, T. Segura

The paper provides simulated granular scaffolds with known void volume fraction (VVF) to study measurement accuracy and reveals VVF may be unreliable as a descriptor.

bioRxiv · Jun 14, 2022Bioengineering

Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge

S. Sun, E. Li, G. Zhao, J. Tang, Q. Zuo, L. Cai, C. Xu, C. Sui, Y. Ou, C. Liu, H. Li, Y. Ding, C. Li, D. Lu, W. Zhang, , S. Guan

This study shows that peptide-poloxamine-DNA nanoparticles provide complete protection against lethal SARS-CoV-2 challenge through robust mucosal immunity.

bioRxiv · May 29, 2022Immunology

Proteogenomic analysis of aneuploidy reveals divergent types of gene expression regulation across cellular pathways

T. Davoli, P. Cheng, X. Zhao, L. Katsnelson, R. Moya, J. Shwetar, D. Fenyo

This study uses proteogenomic analysis to show that gene expression regulation differs across cellular pathways and tissues, with protein-level regulation dominating in some pathways and RNA-level regulation in others.

bioRxiv · Dec 7, 2021 · PreprintCell Biology

Spatiotemporal Dynamics of Intra-tumoral Dependence on NEK2-EZH2 Signaling in Glioblastoma Cancer Progression

J. Wang, M. S. Pavlyukov, D. Yamashita, P. Cheng, Z. Zhang, S.-H. Kim, M. A. Nakano, W. Xie, D. Chen, B. Frett, W.-h. Hu, Y. J. Shin, Y. Lee, V. Goidts, D.-H. Nam, , I. Nakano

This study identifies NEK2-EZH2 signaling as critical for glioblastoma tumor core progression and resistance, and presents a novel inhibitor CMP3a that shows therapeutic potential.

bioRxiv · Dec 1, 2020 · PreprintCancer Biology

Smad3 Regulates Smooth Muscle Cell Fate and Governs Adverse Remodeling and Calcification of Atherosclerotic Plaque

P. Cheng, r. Wirka, J. Kim, T. Nguyen, R. Kundu, q. Zhao, A. Pedroza, M. Nagao, D. Iyer, M. Fischbein, T. Quertermous

This study shows that Smad3 in smooth muscle cells prevents harmful plaque changes in atherosclerosis by blocking specific cell transitions that lead to calcification and inflammation.

bioRxiv · Sep 15, 2020 · PreprintCell Biology

The ERA-related GTPase AtERG2 associated with mitochondria 18S RNA is essential for early embryo development in Arabidopsis

P. Cheng, H. Li, L. Yuan, H. Li, L. Xi, J. Zhang, J. Liu, Y. Wang, H. Zhao, H. Zhao, S. Han

This study identifies AtERG2, a mitochondrial GTPase in Arabidopsis, as essential for early embryo development, with mutants showing seed abortion and ROS accumulation.

bioRxiv · Sep 18, 2017Plant Biology