In depth analysis of kinase cross screening data to identify CAMKK2 inhibitory scaffolds
S. O'Byrne, J. W. Scott, J. R. Pilotte, A. d. S. Santiago, C. G. Langendorf, J. S. Oakhill, B. J. Eduful, R. M. Counago, C. I. Wells, W. Zuercher, T. Willson, D. H. Drewry
This paper reviews CAMKK2's role in biology and disease, identifies starting points for inhibitor development using literature and databases, and highlights potential for selective inhibitors in oncology, metabolism, and inflammation.
bioRxiv · Jan 8, 2020Cancer Biology