Author

J. W. Scott

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:metabolism & bioenergetics· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. S. Oakhill· 5 shared C. G. Langendorf· 3 shared A. J. Ovens· 2 shared C. I. Wells· 2 shared D. Awad· 2 shared D. E. Frigo· 2 shared D. H. Drewry· 2 shared R. M. Counago· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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5 shared papersCancer Biology

J. S. Oakhill

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Author profile →

5 papers

Recent·Most cited

SGC-CAMKK2-1: A chemical probe for CAMKK2

C. I. Wells, Y. Liang, T. L. Pulliam, C. Lin, D. Awad, B. Eduful, S. O Byrne, M. A. Hossain, C. Catta-Preta, P. Zonzini Ramos, O. Gileadi, C. Gileadi, R. M. Counago, B. Stork, C. G. Langendorf, , D. H. Drewry

This paper introduces SGC-CAMKK2-1, a selective chemical probe for CAMKK2, demonstrating its potential as a tool to study the therapeutic benefits of CAMKK2 inhibition.

Cells · Jan 11, 2023Peer-reviewedCancer Biology

Systemic ablation of Camkk2 impairs metastatic colonization and improves insulin sensitivity in TRAMP mice: Evidence for cancer cell-extrinsic CAMKK2 functions in prostate cancer

T. L. Pulliam, D. Awad, J. J. Han, M. M. Murray, J. J. Ackroyd, P. Goli, J. S. Oakhill, J. W. Scott, M. M. Ittmann, D. E. Frigo

This study shows that deleting Camkk2 in TRAMP mice reduces metastasis and improves insulin sensitivity, suggesting CAMKK2 has non-autonomous roles in prostate cancer progression.

bioRxiv · Mar 28, 2022Cancer Biology

Novel torin1-sensitive phosphorylation sites on the metabolic regulator AMPK revealed by label-free mass spectrometry

W. J. Smiles, A. J. Ovens, D. Yu, N. X. Y. Ling, A. Hoque, J. W. Scott, S. Galic, C. G. Langendorf, B. E. Kemp, J. Petersen, J. S. Oakhill

The paper identifies mTORC1-sensitive phosphorylation sites on AMPK using mass spectrometry, revealing their role in regulating nuclear AMPK activity and cell proliferation under nutrient stress.

bioRxiv · Oct 20, 2021 · PreprintBiochemistry

Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle

P. Rhein, E. M. Desjardins, P. Rong, D. Ahwazi, N. Bonhoure, J. Stolte, M. D. Santos, A. J. Ovens, A. M. Ehrlich, J. L. Sanchez Garcia, Q. Ouyang, M. F. Kjolby, M. Membrez, N. Jessen, J. S. Oakhill, , K. Sakamoto

This study shows that AMPKγ3 is essential for AICAR-induced glucose clearance and uptake in glycolytic muscle but not for ADaM drug-induced effects or adipose thermogenesis.

bioRxiv · Mar 5, 2021Physiology

In depth analysis of kinase cross screening data to identify CAMKK2 inhibitory scaffolds

S. O'Byrne, J. W. Scott, J. R. Pilotte, A. d. S. Santiago, C. G. Langendorf, J. S. Oakhill, B. J. Eduful, R. M. Counago, C. I. Wells, W. Zuercher, T. Willson, D. H. Drewry

This paper reviews CAMKK2's role in biology and disease, identifies starting points for inhibitor development using literature and databases, and highlights potential for selective inhibitors in oncology, metabolism, and inflammation.

bioRxiv · Jan 8, 2020Cancer Biology