Author

L. J. Gearing

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

P. Hertzog· 2 shared A. Alvarado· 1 shared A. Barugahare· 1 shared A. E. Clark· 1 shared A. F. Carlin· 1 shared A. Keniry· 1 shared A. Malhotra· 1 shared A. Tapia del Fierro· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

P. Hertzog

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Author profile →

5 papers

Recent·Most cited

Mammalian cells internalize bacteriophages and utilize them as a food source to enhance cellular growth and survival

M. C. Bichet, J. Adderley, L. Avellaneda-Franco, L. J. Gearing, C. Deffrasnes, C. David, G. Pepin, M. P. Gantier, R. C. Lin, R. Patwa, G. W. Moseley, C. Doerig, J. J. Barr

This study shows mammalian cells internalize bacteriophage T4, which enhances cellular growth and survival through AKT-dependent pathways and G1 phase prolongation without triggering inflammatory responses.

bioRxiv · Mar 10, 2023 · PreprintMicrobiology

Constitutive expression and distinct properties of IFN-epsilon protect the female reproductive tract from Zika virus infection

R. Coldbeck-Shackley, O. Romeo, S. Rosli, L. J. Gearing, J. A. Gould, S. S. Lim, K. Van der Hoek, N. S. Eyre, B. Shue, S. A. Robertson, S. M. Best, M. D. Tate, P. Hertzog, M. R. Beard

This paper shows that IFN-epsilon's constitutive expression in the female reproductive tract provides innate antiviral protection against Zika virus by resisting viral antagonism and enhancing antiviral activity.

PLOS Pathogens · Mar 10, 2023Peer-reviewedImmunology

The lung employs an intrinsic surfactant-mediated inflammatory response for viral defense

S. L. Leibel, R. N. McVicar, R. Murad, E. M. Kwong, A. E. Clark, A. Alvarado, B. A. Grimmig, R. Nuryyev, R. E. Young, J. C. Lee, W. Peng, Y. P. Zhu, E. Griffis, C. J. Nowell, B. James, , E. Y. Snyder

This study shows that surfactant proteins mediate an intrinsic inflammatory response in the lung to defend against SARS-CoV-2 infection.

bioRxiv · Jan 26, 2023 · PreprintImmunology

KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation.

J. Li, K. Hardy, M. Olshansky, A. Barugahare, L. J. Gearing, J. E. Prier, X. Y. Sng, M. L. T. Nguyen, D. Piovesan, B. E. Russ, N. L. La Gruta, P. Hertzog, S. Rao, S. J. Turner

This study identifies KDM6B-dependent chromatin remodelling as critical for virus-specific CD8+ T cell differentiation and memory formation.

bioRxiv · Feb 3, 2020 · PreprintImmunology

Xmas ESC: A new female embryonic stem cell system that reveals the BAF complex as a key regulator of the establishment of X chromosome inactivation

A. Keniry, N. Jansz, L. J. Gearing, I. Wanigasuriya, J. Chen, C. M. Nefzger, P. F. Hickey, Q. Gouil, J. Liu, K. Breslin, M. Iminitoff, T. Beck, A. Tapia del Fierro, S. A. Kinkel, P. C. Taberlay, , M. E. Blewitt

The paper introduces a female ESC system called Xmas that identifies the BAF complex as essential for X chromosome inactivation.

bioRxiv · Sep 13, 2019 · PreprintCell Biology