Biophysical dissection of SOX18/NR2F2 transcriptional antagonism reveals mechanisms of venous differentiation and drug action in vascular malformation
Matthew S. Graus, Sawan Kumar Jha, Jieqiong Lou, Annegret Holm, Yew Yan Wong, Tara Davidson, Paul R. Coleman, Ella Sugo, Winnie Luu, Tara Karnezis, Jennifer R. Gamble, Geoffrey William McCaughan, S. L. Nightingale, Joyce E. Bischoff, Kazuaki Maruyama, , Mathias François
This study identifies a biophysical mechanism of SOX18/NR2F2 transcriptional antagonism that governs venous differentiation and shows that inhibiting SOX18 can improve vascular malformation symptoms.
bioRxiv · Apr 25, 2025 · PreprintDevelopmental Biology