Renae Skoczylas

Distinct topologically associated domains underlie the regulatory logic in lymphatic endothelial cells contributing to proper cell differentiation

This study identifies cell type-specific topologically associated domains in lymphatic endothelial cells and defines regulatory networks contributing to their differentiation.

Multiple cis-regulatory elements control prox1a expression in distinct lymphatic vascular beds

This study identifies multiple cis-regulatory elements controlling prox1a expression in distinct lymphatic vascular beds in zebrafish.

The blood vasculature instructs lymphatics patterning in a SOX7-dependent manner

This study identifies SOX7 as a transcription factor in blood vascular endothelial cells that represses Vegfc expression, influencing lymphatic vessel patterning in mice.

Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells

This study identifies that arterial mural cells provide survival and guidance cues via Cxcl12a/b and Vegfc to promote lymphatic endothelial cell migration in zebrafish.

Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice

This study identifies a genetic interaction between Pkd1 and Wnt5a in controlling lymphatic vascular morphogenesis in mice, showing mutual suppression of lymphatic defects.

Vasohibin-1 mediated tubulin detyrosination selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk

This study shows that Vasohibin-1 mediates tubulin detyrosination in zebrafish endothelial cells, selectively regulating secondary sprouting and lymphangiogenesis in the trunk.