Yemin Lan

The paper shows that cleavage of histone H2A by Cathepsin L during ESC differentiation reduces nucleosome stability and counteracts gene activation.

The paper develops HiDRO, a high-throughput imaging pipeline, to screen the human druggable genome and identifies >300 factors regulating chromatin folding, including GSK3A as a regulator of TAD interactions.

This study investigates the role of H19/Igf2 dysregulation in cardiac and placental defects in SRS-like mouse models, showing disrupted ECM and endothelial proliferation pathways.

This study identifies spurious intragenic transcription as a conserved hallmark of mammalian cellular senescence and tissue aging, impacting cellular health and transcriptional networks.

This study shows that NIPBL and WAPL regulate cohesin activity to control chromatin folding and gene expression, with their relative levels determining transcriptional outcomes.

This study investigates how CTCF and transcription influence chromatin structure reconfiguration after mitosis, revealing their distinct roles in boundary formation and gene domain establishment.

The paper identifies ZNF410 as a highly specific transcriptional activator in erythroid cells that regulates CHD4 and fetal hemoglobin expression.

This study examines sex-specific metabolic and transcriptomic effects of IVF in mice, finding sex-dimorphic dysregulation of SREBP pathways and placental DNA methylation changes linked to cholesterol levels.

This study shows that FoxA factors are essential for maintaining the hepatic gene regulatory network in adult mice, as their loss leads to rapid hepatocyte dedifferentiation and lethality.

The paper examines how chromatin structures re-establish after mitosis using Hi-C, showing rapid compartment formation and dynamics of CTCF and cohesin binding.