Aquaporin-4 dependent glymphatic solute transport in rodent brain
Humberto Mestre, Lauren M. Hablitz, Anna L. R. Xavier, Weixi Feng, Wenyan Zou, Tinglin Pu, Hiromu Monai, Giridhar Murlidharan, Ruth M. Castellanos Rivera, Matthew J. Simon, Martin M. Pike, Virginia Plá, Ting Du, Benjamin T. Kress, Xiaowen Wang, , Maiken Nedergaard
This study confirms that AQP4 is essential for glymphatic fluid and solute transport in the rodent brain, as Aqp4 disruption reduces CSF influx and amyloid-beta efflux.
eLife · Dec 18, 2018Peer-reviewedNeuroscience