Author

Tony Tuck

Boston University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:clustering· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Julia TCWiD· 2 shared Adeline E. WalshiD· 1 shared Alexandre PelletieriD· 1 shared Amy A. Gorman· 1 shared Danielle S. Goulding· 1 shared Diana J. ZajaciD· 1 shared Douglas A. HarrisoniD· 1 shared Holden C. WilliamsiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenomics

Julia TCWORCID

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Author profile →

2 papers

Recent·Most cited

Factorization of Alzheimer's disease genetic risk influences allow patient stratification, predicting disease onset, cognitive decline, and cell-type specific responses

Alexandre Pelletier, Tony Tuck, Julia TCW

The paper uses matrix factorization to analyze genetic risk variants in Alzheimer's disease, identifying factors that predict disease onset, cognitive decline, and cell-type specific responses.

bioRxiv · Jan 8, 2026 · PreprintGenomics

ApoE4 drives maladaptive heterogeneity and immunometabolic responses of astrocytes

Sangderk Lee, Holden C. Williams, Amy A. Gorman, Nicholas A. Devanney, Douglas A. Harrison, Adeline E. Walsh, Danielle S. Goulding, Tony Tuck, James L. Schwartz, Diana J. Zajac, Shannon L. Macauley, Steven Estus, Julia TCW, Lance A. Johnson, Josh M. Morganti

This study shows that ApoE4 alters astrocyte immunometabolic responses to inflammation by changing their transcriptional profiles and relying on cRel transcription factor activity.

bioRxiv · Feb 6, 2023 · PreprintNeuroscience