Author

Amy A. Gorman

University of Kentucky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Josh M. MorgantiiD· 3 shared Adeline E. WalshiD· 2 shared Danielle S. Goulding· 2 shared Holden C. WilliamsiD· 2 shared James L. Schwartz· 2 shared Lance A. JohnsoniD· 2 shared Nicholas A. DevanneyiD· 2 shared Sangderk LeeiD· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersNeuroscience

Josh M. MorgantiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge

Sangderk Lee, Nicholas A. Devanney, Lesley R. Golden, Cathryn T Smith, James L. Schwartz, Adeline E. Walsh, Harrison A. Clarke, Danielle S. Goulding, Elizabeth J. Allenger, Gabriella Morillo Segovia, Cassi M. Friday, Amy A. Gorman, Tara R. Hawkinson, Steven M. MacLean, Holden C. Williams, , Lance A. Johnson

This study investigates how APOE4 affects microglial immunometabolism across age, amyloid pathology, and inflammation using multi-omics approaches.

Cell Reports · Mar 1, 2023Peer-reviewedNeuroscience

ApoE4 drives maladaptive heterogeneity and immunometabolic responses of astrocytes

Sangderk Lee, Holden C. Williams, Amy A. Gorman, Nicholas A. Devanney, Douglas A. Harrison, Adeline E. Walsh, Danielle S. Goulding, Tony Tuck, James L. Schwartz, Diana J. Zajac, Shannon L. Macauley, Steven Estus, Julia TCW, Lance A. Johnson, Josh M. Morganti

This study shows that ApoE4 alters astrocyte immunometabolic responses to inflammation by changing their transcriptional profiles and relying on cRel transcription factor activity.

bioRxiv · Feb 6, 2023 · PreprintNeuroscience

Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice

Alexandria N Early, Amy A. Gorman, Linda J. Van Eldik, Adam D. Bachstetter, Josh M. Morganti

This study investigates how aging affects astrocyte responses to traumatic brain injury in mice, finding age-related impairments in homeostatic functions and altered reactive astrogliosis.

Journal of Neuroinflammation · Apr 14, 2020Peer-reviewedNeuroscience