Author

James L. Schwartz

University of Kentucky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:scRNA-seq· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Adeline E. WalshiD· 2 shared Amy A. Gorman· 2 shared Danielle S. Goulding· 2 shared Holden C. WilliamsiD· 2 shared Josh M. MorgantiiD· 2 shared Lance A. JohnsoniD· 2 shared Nicholas A. DevanneyiD· 2 shared Sangderk LeeiD· 2 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersNeuroscience

Adeline E. WalshORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge

Sangderk Lee, Nicholas A. Devanney, Lesley R. Golden, Cathryn T Smith, James L. Schwartz, Adeline E. Walsh, Harrison A. Clarke, Danielle S. Goulding, Elizabeth J. Allenger, Gabriella Morillo Segovia, Cassi M. Friday, Amy A. Gorman, Tara R. Hawkinson, Steven M. MacLean, Holden C. Williams, , Lance A. Johnson

This study investigates how APOE4 affects microglial immunometabolism across age, amyloid pathology, and inflammation using multi-omics approaches.

Cell Reports · Mar 1, 2023Peer-reviewedNeuroscience

ApoE4 drives maladaptive heterogeneity and immunometabolic responses of astrocytes

Sangderk Lee, Holden C. Williams, Amy A. Gorman, Nicholas A. Devanney, Douglas A. Harrison, Adeline E. Walsh, Danielle S. Goulding, Tony Tuck, James L. Schwartz, Diana J. Zajac, Shannon L. Macauley, Steven Estus, Julia TCW, Lance A. Johnson, Josh M. Morganti

This study shows that ApoE4 alters astrocyte immunometabolic responses to inflammation by changing their transcriptional profiles and relying on cRel transcription factor activity.

bioRxiv · Feb 6, 2023 · PreprintNeuroscience