Author

V. Amarnath

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

M. F. Linton· 3 shared P. G. Yancey· 3 shared S. S. Davies· 3 shared H. Tao· 2 shared J. Huang· 2 shared L. Ding· 2 shared V. Yermalitsky· 2 shared Y. Zhang· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersPharmacology & Toxicology

M. F. Linton

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4 papers

Recent·Most cited

Immunoproteasomal Processing of Isolevuglandin Adducts in Hypertension

N. de la Visitacion, W. Chen, J. Krishnan, J. P. Van Beusecum, V. Amarnath, E. M. Hennen, S. Zhao, M. Saleem, M. Ao, D. G. Harrison, D. M. Patrick

This study identifies the immunoproteasome's role in processing and presenting isoLG-adducts, linking it to hypertension and inflammation.

Circulation Research · May 10, 2024Peer-reviewedImmunology

Scavenging dicarbonyls with 5'-O-pentyl-pyridoxamine increases HDL net cholesterol efflux capacity and attenuates atherosclerosis and insulin resistance

J. Huang, H. Tao, P. G. Yancey, Z. Leuthner, L. May-Zhang, J.-Y. Jung, Y. Zhang, L. Ding, V. Amarnath, D. Liu, S. Collins, S. S. Davies, M. F. Linton

This study shows that scavenging reactive dicarbonyls with PPM reduces atherosclerosis and insulin resistance in Ldlr-/- mice by improving HDL function and reducing inflammation.

bioRxiv · Nov 18, 2022Pharmacology & Toxicology

Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr-/- mice

H. Tao, J. Huang, P. G. Yancey, V. Yermalitsky, L. Ding, Y. Zhang, J. L. Blakemore, I. Zagol-Ikapitte, V. Amarnath, O. Boutaud, J. A. Oates, L. J. Roberts, S. S. Davies, M. F. Linton

This study shows that 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic mice by scavenging reactive dicarbonyls and improving HDL function.

bioRxiv · Aug 23, 2019 · PreprintPharmacology & Toxicology

4-oxo-2-nonenal Adducts In HDL Are Elevated In Familial Hypercholesterolemia: Identification Of Modified Sites And Functional Consequences

L. S. May-Zhang, V. Yermalitsky, J. T. Melchior, J. Morris, K. A. Tallman, M. S. Borja, T. Pleasent, V. Amarnath, P. G. Yancey, W. S. Davidson, M. F. Linton, S. S. Davies

This study identifies elevated 4-oxo-2-nonenal (ONE) adducts in HDL from familial hypercholesterolemia patients and shows their functional impact on HDL function and macrophage responses.

bioRxiv · May 12, 2019Biochemistry