S. S. Davies

Plaat1l1 controls feeding induced NAPE biosynthesis and contributes to energy balance regulation in zebrafish.

This study identifies plaat1l1 as a key enzyme for feeding-induced NAPE biosynthesis in zebrafish, showing its role in energy balance regulation and obesity prevention.

Discovery of post-translationally modified self-peptides that promote hypertension

The paper identifies post-translationally modified self-peptides linked to hypertension using a combined computational and experimental approach.

Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages

This study identifies small molecule activators of NAPE-PLD that enhance efferocytosis by macrophages, suggesting their potential therapeutic use in cardiometabolic diseases.

Scavenging dicarbonyls with 5'-O-pentyl-pyridoxamine increases HDL net cholesterol efflux capacity and attenuates atherosclerosis and insulin resistance

This study shows that scavenging reactive dicarbonyls with PPM reduces atherosclerosis and insulin resistance in Ldlr-/- mice by improving HDL function and reducing inflammation.

Symmetrically substituted dichlorophenes inhibit N-acyl-phosphatidylethanolamine phospholipase D

This study identifies symmetrically substituted dichlorophenes as potent and selective inhibitors of NAPE-PLD, with IC50 values around 2 M.

Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr-/- mice

This study shows that 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic mice by scavenging reactive dicarbonyls and improving HDL function.

4-oxo-2-nonenal Adducts In HDL Are Elevated In Familial Hypercholesterolemia: Identification Of Modified Sites And Functional Consequences

This study identifies elevated 4-oxo-2-nonenal (ONE) adducts in HDL from familial hypercholesterolemia patients and shows their functional impact on HDL function and macrophage responses.

Reactive Dicarbonyl Scavenging Effectively Reduces MPO-Mediated Oxidation of HDL and Preserves HDL Atheroprotective Functions

This study shows that reactive dicarbonyl scavengers reduce MPO-mediated HDL oxidation, preserve HDL function, and improve cholesterol efflux in FH-HDL and mice.